Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles
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Cites background or result from "Oxidative stress in cancer and fibr..."
...Similarly, clinical trial results have been largely disappointing [162]....
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...Further roles of ROS in cancer have been reviewed previously [14, 154, 162]....
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157 citations
157 citations
Cites background from "Oxidative stress in cancer and fibr..."
...Inhibition of ROS and other free radicals is a logical therapeutic intervention for fibrosis [145]....
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...As enormous generation of ROS initiates and progress the cancer cell proliferation, it also induces the fibrosis [145]....
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References
6,036 citations
"Oxidative stress in cancer and fibr..." refers background in this paper
...The downstream effects of the EMT response include transcriptional reprogramming which promotes inactivation of genes (such as E-cadherin) that encodes for epithelial markers and activation of genes for mesenchymal proteins such as N-cadherin and vimentin [69,70]....
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5,873 citations
"Oxidative stress in cancer and fibr..." refers background or methods in this paper
...Extensive details on the structure and activation of NOX isoforms have been reviewed elsewhere [4,82,85]....
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...Reproduced with permission from The American Physiological Society [4]....
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...ROS can be generated either by exogenous sources such as UV radiation, toxic chemicals and drugs, physiological changes such as aging or injury/ inflammation [22], or by intracellular (endogenous) sources such as NOX enzymes on the plasma membrane [4], myeloperoxidases (MPO) in phagocytes [23], and as by-products of respiratory chain function in mitochondria [3]....
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...Several sources of ROS in cells and tissue have been identified, including mitochondrial electron transfer chain [3] and NADPH oxidase (NOX) enzymes [4]....
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...ROS are generally defined as oxygen-containing small species including superoxide anion radical (O2 ), hydroxyl radical (OH), hydroxyl ion (OH), hydrogen peroxide (H2O2), singlet oxygen ( (1)O2), and ozone (O3) [4,21]....
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4,369 citations
"Oxidative stress in cancer and fibr..." refers background in this paper
...All these events will eventually lead to an increase in intracellular ROS production in a positive-feedback manner [54]....
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