Oxidative stress in the pathology and treatment of systemic lupus erythematosus.
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Cites background from "Oxidative stress in the pathology a..."
...Multiple mechanisms are responsible for mitochondrial abnormalities in lupus T cells, including enhanced mitochondrial biogenesis and insufficient mitophagy [153]....
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210 citations
Cites background from "Oxidative stress in the pathology a..."
...In addition, oxidative stress depletes NADPH and glutathione levels leading to mTOR activation which also exacerbates the DNA methylation defect by inhibiting DNMT1 [19]....
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...Oxidative stress has been shown to inhibit DNA methylation in lupus T cells by blocking PKC-δ activation, resulting in attenuated MEK/ERK signaling and reduced expression of the main DNA methyltransferase DNMT1 [17, 18]....
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...In addition, oxidative stress depletes NADPH and glutathione levels leading to mTOR activation which also exacerbates the DNA methylation defect by inhibiting DNMT1 [19]....
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