Oxidative Stress, Prooxidants, and Antioxidants: The Interplay
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1,317 citations
Cites background from "Oxidative Stress, Prooxidants, and ..."
...Moreover, α-lipoic acid exerts a protective effect on the kidney of diabetic rats but a prooxidant effect in nondiabetic animals [189]....
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...The pro-oxidant effects have been attributed to dehydroxylipoic acid (DHLA), the reduced metabolite of α-lipoic acid owing to its ability to reduce iron, initiate reactive sulfurcontaining radicals, and thus damage proteins such as alpha 1-antiproteinase and creatine kinase playing a role in renal homeostasis [189]....
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...Furthermore, some negative effects of antioxidants when used in dietary supplements (ascorbic acid, flavanoids, carotenoids, α-lipoic acid and synthetic compounds) have came out in the last few decades [189]....
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1,114 citations
Cites background from "Oxidative Stress, Prooxidants, and ..."
...At high levels, these toxicants can cause damage to cellular components, including proteins, lipids, and DNA (133)....
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...In human cells, CDK12 has been identified as an essential regulator for the transcription of various DNA damage response and DNA repair genes, increasing the interest in the development of pharmacological inhibitors of CDK12 to act as sensitizers to chemotherapeutic agents (64, 94)....
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...BRG1, the central ATPase subunit of the SWI/SNF chromatinremodeling complex, has been shown to interact with NRF2 and to selectively influence the transcription of NRF2 target genes with Z-DNA formation (193)....
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...Together with histone-modifying enzymes, Nrf2 recruits Mediator, a multi-subunit protein complex that communicates the activation signals from a DNA-bound transcription factor to RNA polymerase II (Pol II) (6, 143)....
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...Moreover, NRF2 associates with other co-activators of the transcription machinery, such as chromodomain helicase DNA-binding protein 6 (CHD6) (120), receptor-associated co-activator 3 (RAC3) (75), and NAD+-dependent histone deacetylase sirtuin 6 (SIRT6) (128)....
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920 citations
Cites background from "Oxidative Stress, Prooxidants, and ..."
...Because it is clear that, along with antioxidants, pro-oxidants also play crucial role in oxidative stress and diseases, the awareness around pro-oxidants is equally important to combat OS and neurodegeneration [40,41]....
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698 citations
613 citations
Cites background from "Oxidative Stress, Prooxidants, and ..."
...Increased expression of catalase and peroxiredoxin 1 molecules are considered as OS markers [20–22]....
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References
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"Oxidative Stress, Prooxidants, and ..." refers background in this paper
...This is the result of the electron transport chain located in themitochondrialmembrane,which is essential for the energy production inside the cell [56, 57]....
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5,468 citations
"Oxidative Stress, Prooxidants, and ..." refers background in this paper
...Regular chewing of tobacco alongwith inadequate diet is the most prominent finding to mortality due to lung cancer in USA [3]....
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