Oxidized Low Density Lipoprotein Activates Peroxisome Proliferator-activated Receptor-α (PPARα) and PPARγ through MAPK-dependent COX-2 Expression in Macrophages
Kayo Taketa,Takeshi Matsumura,Miyuki Yano,Norio Ishii,Takafumi Senokuchi,Hiroyuki Motoshima,Yusuke Murata,Shokei Kim-Mitsuyama,Teruo Kawada,Hiroyuki Itabe,Motohiro Takeya,Takeshi Nishikawa,Kaku Tsuruzoe,Eiichi Araki +13 more
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TLDR
Ox-LDL-induced increase in 15d-PGJ2 level through ERK1/2-dependent COX-2 expression is one of the mechanisms of PPARα and PPARγ activation in macrophages, and may control excess atherosclerotic progression.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-04-11 and is currently open access. It has received 60 citations till now. The article focuses on the topics: Peroxisome proliferator-activated receptor.read more
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Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis
Yuan Yuan,Peng Li,Jing Ye +2 more
TL;DR: This review focuses on the potential mechanisms of formation of macrophage-derived foam cells in atherosclerosis with particular emphasis on the role of lipid homeostasis and lipid droplet-associated proteins.
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Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation.
TL;DR: Evidence has emerged that oxidized phospholipids also have protective effects in some situations and cell types; a notable example is their ability to interfere with signaling by certain Toll-like receptors induced by microbial products that normally leads to inflammation.
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Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression.
Paola Palozza,Rossella Emanuela Simone,Assunta Catalano,Giovanni Monego,Angelina Barini,Maria Cristina Mele,Nadia Parrone,Sonia Trombino,Nevio Picci,Franco O. Ranelletti +9 more
TL;DR: Whether lycopene is able to counteract oxysterol-induced proinflammatory cytokines cascade in human macrophages is investigated, limiting the formation of atherosclerotic plaque and new information is brought on the anti-atherogenic properties of lycopenes, and on its mechanisms of action in atherosclerosis prevention.
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Activation of transcription factors and gene expression by oxidized low-density lipoprotein
C. Mazière,Jean-Claude Mazière +1 more
TL;DR: Identification of the transcription factors and some of the downstream genes regulated by OxLDL has helped to understand the molecular mechanism involved in generation of the atherosclerotic plaque.
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Role of Ca2+-independent phospholipase A2 in cell growth and signaling
TL;DR: The role of iPLA(2) in cell growth is discussed with special emphasis placed on their role in cell signaling and the putative lipid signals involved are also discussed.
References
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A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.