Oxytocin and Reduction of Social Threat Hypersensitivity in Women With Borderline Personality Disorder
Citations
45 citations
Cites background from "Oxytocin and Reduction of Social Th..."
...In addition, increased attention toward the eye region of facial stimuli (measured by eye gaze or reaction time) has been found after oxytocin administration (Bertsch et al., 2013; Brune et al., 2013; Domes et al., 2013; Tollenaar et al., 2013)....
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...) to negative (decreased trust and cooperation) (Bartz et al., 2011a; Bertsch et al., 2013; Brune et al., 2013; Ebert et al., 2013; Simeon et al., 2011)....
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43 citations
Cites background or methods or result from "Oxytocin and Reduction of Social Th..."
...Of note, in healthy women, OT administration has previously been demonstrated to enhance left (Domes et al., 2010) and right (Bertsch et al., 2013) amygdala reactivity to fearful (Domes et al., 2010) and angry (Bertsch et al., 2013) facial expressions....
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..., 2010) and angry (Bertsch et al., 2013) facial expressions....
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...However, the results are in contrast with findings in healthy men (Kirsch et al., 2005; Domes et al., 2007; Gamer et al., 2010), male GSAD patients (Labuschagne et al., 2010), and women with BPD (Bertsch et al., 2013) and contrary to our expectations for recently trauma-exposed individuals....
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...right amygdala reactivity to angry (Bertsch et al., 2013), and left...
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...Of note, in BPD patients, in contrast to findings of beneficial OT effects on stress and fear processing (Simeon et al., 2011; Bertsch et al., 2013), adverse effects from OT administration on social behavior were also observed (Bartz et al....
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43 citations
42 citations
Cites background or result from "Oxytocin and Reduction of Social Th..."
...Although the exact reasons for these divergent results remain unclear, some important differences in the experimental settings need to be considered: The previously reported results (Bertsch et al., 2013) were found in a pharmacological stimulation study in which participants classified briefly presented (150 ms) angry, fearful, and happy faces in the MRI scanner after a nasal administration of oxytocin or a placebo....
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...With regard to the eye-tracking data, we expected an enhanced proportion as well as a shorter latency of initial saccades towards the eyes of threatening (angry and fearful) faces in patients with BPD compared with healthy volunteers in both presentation time conditions, replicating our former findings (Bertsch et al., 2013)....
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...Similar to our former study (Bertsch et al., 2013), patients with BPD and healthy volunteers took part in an emotion classification task with angry, fearful, happy—and this time also neutral—faces initially fixated at the mouth or eye region....
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...So far, reflexive saccades during facial emotion processing in patients with BPD have only been assessed in one study (Bertsch et al., 2013)....
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...In some regards, the results of the present study differ from those of our previous eye-tracking study (Bertsch et al., 2013), in which we found more and faster initial saccades towards the eyes of angry and fearful faces as well as faster responses to angry faces in the total sample of patients with BPD compared with healthy volunteers....
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40 citations
References
13,678 citations
"Oxytocin and Reduction of Social Th..." refers methods in this paper
...Since we hypothesized modulatory effects of oxytocin in the amygdala, we applied a small-volume correction for multiple comparisons in predefined bilateral anatomical amygdala regions of interest (35)....
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1,760 citations
"Oxytocin and Reduction of Social Th..." refers background in this paper
...In healthy individuals, the intranasal administration of oxytocin reduces anxiety and stress in social situations (15), enhances the recognition of facial expressions (16–19), and shifts attention from negative to positive information (20–22), although individual differences and situational factors seem to play an important role (23)....
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1,515 citations
"Oxytocin and Reduction of Social Th..." refers methods in this paper
...Anatomical labels for subregions within the amygdala were specified by comparing the location of activation clusters with high-resolution diagrams of the human amygdala as depicted in an anatomical atlas (36)....
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1,477 citations
"Oxytocin and Reduction of Social Th..." refers background in this paper
...anterior) amygdala to negative emotional stimuli (13, 25, 26), whichmay reflect a neural mechanism of its anxiolytic properties (24, 26)....
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1,436 citations
"Oxytocin and Reduction of Social Th..." refers background in this paper
...It has therefore been suggested that borderline patients who are hypersensitive to negative, threatening social information may benefit from intranasal oxytocin administration (29)....
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