P-glycoprotein: from genomics to mechanism
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"P-glycoprotein: from genomics to me..." refers background in this paper
...Subsequently, other members of this family of transporters such as MRP1 (ABCC1) and MXR (ABCG2) have been shown to be capable of conferring MDR by virtue of energydependent drug efflux (reviewed in Litman et al., 2001; Borst and Elferink, 2002; Gottesman et al., 2002)....
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...In addition, we have suggested that some of the ABC transporters, such as P-gp, might prove useful as selectable markers for gene therapy, or to protect bone marrow during cancer therapy (Gottesman et al., 2002)....
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...Although there have been several generations of P-gp modulators in development, reversing P-gp-mediated MDR in the clinic has met with very limited success (Gottesman et al., 2002; Leonard et al., 2002)....
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3,591 citations
"P-glycoprotein: from genomics to me..." refers background in this paper
...Some of these agents may carry a positive charge at physiological pH, but due to their amphipathic nature they can enter cells by passive diffusion (Gottesman and Pastan, 1993)....
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3,030 citations
"P-glycoprotein: from genomics to me..." refers background in this paper
...Subsequently, MRP1 (ABC C1) was isolated from an MDR lung cancer cell line where MDR1 was not expressed (Cole et al., 1992)....
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...…Glutathione and other conjugates, organic anions, leukotriene C4 Doxorubicin, epirubicin, etoposide, vincristine, methotrexate Borst et al. (2000); Cole et al. (1992); Jedlitschky et al. (1996); Loe et al. (1998); Muller et al. (1994) MRP2, cMOAT ABCC2 Liver, kidney, intestine Similar to MRP1,…...
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2,452 citations
"P-glycoprotein: from genomics to me..." refers background or result in this paper
...A methodical screening for polymorphisms of the entire MDR1 gene, performed by Hoffmeyer et al. (2000) on a healthy Caucasian population, revealed 15 different SNPs in exons and introns....
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...Another explanation for the same phenomenon is that the Caucasian white population was undefined or not divided into specific ethnic groups (Hoffmeyer et al., 2000), while other studies investigated narrower populations (Decleves et al., 2000; Cascorbi et al., 2001)....
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...…of P-gp, and increased digoxin bioavailability; individuals carrying the CC genotype were found to have high intestinal P-gp levels and low intestinal digoxin uptake, while individuals carrying the TT genotype had low intestinal P-gp levels and high digoxin uptake (Hoffmeyer et al., 2000)....
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...Another study examined 268 Caucasian men, half of whom were lung cancer patients, and found similar frequencies of genotypes to Hoffmeyer et al. (2000) (Sinues et al., 2003)....
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...However, a frequency of 13.3% homozygosity for the same allele was found in Caucasians (Hoffmeyer et al., 2000)....
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2,235 citations