Journal ArticleDOI
Paediatric index of mortality 3: an updated model for predicting mortality in pediatric intensive care*.
Lahn Straney,Archie C. A. Clements,Roger C Parslow,Gale Pearson,Frank Shann,Janet Alexander,Anthony Slater +6 more
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TLDR
The Paediatric Index of Mortality 3 provides an international standard based on a large contemporary dataset for the comparison of risk-adjusted mortality among children admitted to intensive care.Abstract:
Objectives: To provide an updated version of the Paediatric Index of Mortality 2 for assessing the risk of mortality among children admitted to an ICU.read more
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Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study
Scott L. Weiss,Julie C. Fitzgerald,John Pappachan,Derek S. Wheeler,Juan C. Jaramillo-Bustamante,Asma Salloo,Sunit C. Singhi,Simon Erickson,Jason Roy,Jenny Bush,Vinay M. Nadkarni,Neal J. Thomas +11 more
TL;DR: Pediatric severe sepsis remains a burdensome public health problem, with prevalence, morbidity, and mortality rates similar to those reported in critically ill adult populations.
Journal ArticleDOI
Pediatric Extracorporeal Life Support Organization Registry International Report 2016.
Ryan P. Barbaro,Matthew L. Paden,Yigit S. Guner,Lakshmi Raman,Lindsay M. Ryerson,Peta M. A. Alexander,Viviane G. Nasr,Melania M. Bembea,Peter Rycus,Ravi R. Thiagarajan +9 more
TL;DR: Adverse events including neurologic events were common during ECLS, a fact that underscores the opportunity and need to promote quality improvement work.
Journal ArticleDOI
Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study.
Luregn J. Schlapbach,Luregn J. Schlapbach,Lahn Straney,Janet Alexander,Graeme MacLaren,Graeme MacLaren,Graeme MacLaren,Marino Festa,Andreas Schibler,Andreas Schibler,Anthony Slater +10 more
TL;DR: Severe infections remain a major cause of mortality in paediatric ICUs, representing a major public health problem, and future studies should focus on patients with the highest risk of poor outcome, and assess the effectiveness of present sepsis interventions in children.
Journal ArticleDOI
Delirium and Mortality in Critically Ill Children: Epidemiology and Outcomes of Pediatric Delirium.
Chani Traube,Gabrielle Silver,Linda M. Gerber,Savneet Kaur,Elizabeth Mauer,Abigail Kerson,Christine Joyce,Bruce M. Greenwald +7 more
TL;DR: The frequency of delirium in critically ill children, its duration, associated risk factors, and effect on in-hospital outcomes, including mortality are described, with a strong and independent predictor of mortality.
Journal ArticleDOI
The Pediatric Risk of Mortality Score: Update 2015*
Murray M. Pollack,Richard Holubkov,Tomohiko Funai,J. Michael Dean,John T. Berger,David L. Wessel,Kathleen L. Meert,Robert A. Berg,Christopher J. L. Newth,Rick Harrison,Joseph A. Carcillo,Heidi J. Dalton,Thomas P. Shanley,Tammara L. Jenkins,Robert F. Tamburro,Carol Nicholson +15 more
TL;DR: The new Pediatric Risk of Mortality data collection methods include significant improvements that minimize the potential for bias and errors, and the newPediatric risk-based prediction algorithm for survival and death has excellent prediction performance.
References
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A method of comparing the areas under receiver operating characteristic curves derived from the same cases.
TL;DR: This paper refines the statistical comparison of the areas under two ROC curves derived from the same set of patients by taking into account the correlation between the areas that is induced by the paired nature of the data.
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A comparison of goodness-of-fit tests for the logistic regression model.
TL;DR: An examination of the performance of the tests when the correct model has a quadratic term but a model containing only the linear term has been fit shows that the Pearson chi-square, the unweighted sum-of-squares, the Hosmer-Lemeshow decile of risk, the smoothed residual sum- of-Squares and Stukel's score test, have power exceeding 50 per cent to detect moderate departures from linearity.
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PRISM III: An updated Pediatric Risk of Mortality score
TL;DR: A third-generation pediatric physiology-based score for mortality risk, Pediatric Risk of Mortality III (PRISM III), was developed and validated and resulted in several improvements over the original PRISM.
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Acute Physiology and Chronic Health Evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patients.
TL;DR: APACHE IV predictions of hospital mortality have good discrimination and calibration and should be useful for benchmarking performance in U.S. ICUs, and aggregate mortality was systematically overestimated as model age increased.
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Obstructive Sleep Apnea
TL;DR: The nature and consequences of upper-airway obstruction in adults during sleep has evolved considerably over the past two decades, and there is insufficient awareness of sleep apnea among physicians and the public at large.