Pain and temperature processing in dementia: a clinical and neuroanatomical analysis
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Cites background from "Pain and temperature processing in ..."
...Unlike previous research investigating sensory processing in dementia, which mostly focused on somatosensory functions [13, 14, 29], the HSS Sensory Factor measures the emergence of behaviors related to various sensory functions, including sensitivity to brightness, loudness, food texture, or the attention to detailed information....
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...Disrupted processing of temperature and pain signals have been recently reported in bvFTD and AD [14], associated with atrophy of the anterior insula, particularly on the right....
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...In addition to these reported changes in cognitive skills, changes in sensory functions with dementia have also been reported, such as an increase of sensitivity or hypersensitivity for pain or temperature [13, 14]....
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References
9,940 citations
"Pain and temperature processing in ..." refers background in this paper
...1 (Desikan et al., 2006; Jenkinson et al., 2012) to fit the group mean template brain image....
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6,999 citations
"Pain and temperature processing in ..." refers methods in this paper
...Preprocessing of patients’ brain magnetic resonance images for VBM was performed using New Segment (Ashburner and Friston, 2005) and the DARTEL (Ashburner, 2007) toolbox of SPM8 (www....
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...A study-specific group mean template brain image was created by warping all native space whole-brain images to the final DARTEL template and calculating the average of the warped brain images....
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...Preprocessing of patients’ brain magnetic resonance images for VBM was performed using New Segment (Ashburner and Friston, 2005) and the DARTEL (Ashburner, 2007) toolbox of SPM8 (www.fil.ion.ucl.ac.uk/spm) running under Matlab7....
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6,049 citations
"Pain and temperature processing in ..." refers background in this paper
...More anterior insular regions are also targeted in PNFA, providing a candidate locus for altered homeostatic awareness in this syndrome (Seeley et al., 2009)....
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5,279 citations
"Pain and temperature processing in ..." refers background or methods or result in this paper
...Such noisy processing might involve degraded temporal scheduling of salient sensory and emotional signals, a key function attributed to anterior insula that is vulnerable in FTLD (Wiener and Coslett, 2008; Craig, 2009; Henley et al., 2014)....
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...Together these networks have a core role in regulation of bodily homeostasis: current neurobiological formulations emphasize convergent processing of somatic and visceral pain and thermoregulatory signals as functionally interdependent aspects of interoception (Craig, 2002, 2009)....
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...…labelled lines have been incorporated by current models that emphasize the intimate association of pain and thermal information and their integration as joint aspects of interoception, salient sensory phenomena that are potentially critical for signalling body homeostasis (Craig, 2002, 2009)....
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...…neural networks that are engaged jointly by these diverse phenomena and reaffirms the primacy of the thalamo-insular linkage in regulating the interface between homeostatic and environmental contingencies, reward and punishment (Craig, 2002, 2009; Perry et al., 2014; Zhou and Seeley, 2014)....
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...This region may be involved in generating subjective psychological states via projections to anterior insula, anterior cingulate, orbitofrontal and prefrontal cortices and in programming coherent autonomic effector responses (Craig, 2002, 2009; Grecucci et al., 2013; Zhou and Seeley, 2014)....
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4,673 citations
"Pain and temperature processing in ..." refers background or methods or result in this paper
...The present evidence suggests a model for synthesizing neurodegenerative disease effects on these cortical operations that is consistent both with data from normal neurophysiological and functional neuroimaging work and the effects of focal brain lesions (Craig, 2002, 2009; Borsook, 2012)....
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...…interpretation, as under most circumstances thermal comfort or distress reflects the degree of perceived mismatch between one’s own body temperature and the environment; temperature sensibility might therefore be regarded as a probe of interoceptive signal processing par excellence (Craig, 2002)....
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...Peripheral somatic and visceral sensory afferents conveying pain and thermal information relay via postero-lateral thalamic nuclei to somatosensory cortex (Brodmann area 3a) and dorsal posterior insula (Craig, 2002)....
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...Temperature sensibility is mediated by a closely overlapping network (Craig, 2002; Moulton et al., 2012)....
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...Together these networks have a core role in regulation of bodily homeostasis: current neurobiological formulations emphasize convergent processing of somatic and visceral pain and thermoregulatory signals as functionally interdependent aspects of interoception (Craig, 2002, 2009)....
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