Palladium‐Catalyzed Olefination of Aryl C—H Bonds by Using Directing Scaffolds
TL;DR: A short review of recent progress in palladium-catalyzed directing groups/template-assisted ortho/meta-C-H olefination can be found in this article.
Abstract: Site selective C–H bond activation/C–C bond formation is an ideal target for organic chemists owing to the ubiquitous nature of C–H bonds in natural products. A particular aryl C–H bond can be predictably activated by a directing group. However, the majority of strong and weak coordinating directing groups have been implemented for ortho-C–H bond activation/C-alkenylation. More recently, meta-C–H functionalization has been promoted by fine-tuning directing templates. In this short review, we have summarized recent progress in palladium-catalyzed directing group/template-assisted ortho/meta-C–H olefination. 1 Introduction 2 Proximal C–H Olefination 3 Distal C–H Olefination 4 Conclusions
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01 Jun 2018
TL;DR: The selective functionalization of inert C-H bonds is always challenging due to their abundance and large bond dissociation energies as mentioned in this paper, despite recent advancements, the engagement of inert building b...
Abstract: The selective functionalization of inert C-H bonds is always challenging due to their abundance and large bond dissociation energies. Despite recent advancements, the engagement of inert building b...
30 citations
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TL;DR: A short review of recent progress in palladium-catalyzed directing groups/template-assisted ortho/meta-C-H olefination can be found in this article.
Abstract: Site selective C–H bond activation/C–C bond formation is an ideal target for organic chemists owing to the ubiquitous nature of C–H bonds in natural products. A particular aryl C–H bond can be predictably activated by a directing group. However, the majority of strong and weak coordinating directing groups have been implemented for ortho-C–H bond activation/C-alkenylation. More recently, meta-C–H functionalization has been promoted by fine-tuning directing templates. In this short review, we have summarized recent progress in palladium-catalyzed directing group/template-assisted ortho/meta-C–H olefination. 1 Introduction 2 Proximal C–H Olefination 3 Distal C–H Olefination 4 Conclusions
39 citations