Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.
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270 citations
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...ATP release via pannexin 1 channels in endothelium promotes leukocyte adhesion and emigration.(113) ATP releases ATP from human leukocytes via P2Y 2,4,6, and 11 receptors....
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179 citations
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...Thus, in HFD-fed ATKOmice, increased AMPK-induced ATP synthesis and TNF-a-stimulated ATP release (Lohman et al., 2015) may exacerbate adipose inflammation via increasing extracellular ATP....
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174 citations
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...In blood vessels, Panx1 in smooth muscle cells is involved in the regulation of vascular tone (Billaud et al., 2012), whereas its presence in venous endothelial cells regulates leukocyte migration during inflammation (Lohman et al., 2015; reviewed in Good et al., 2015; Begandt et al., 2017)....
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153 citations
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...NAT COMMUN 2015 Pannexin-1 Endothelial cells (HUVEC) TNF α released upon inflammation induces ATP release from vascular endothelial cells via PANX1 [29]...
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...induces pannexin-1 opening and ATP release from vascular endothelial cells [29]....
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142 citations
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...Src kinase-mediated tyrosine phosphorylation following the activation of NMDA receptors [121–123], TNFα receptors [124], and P2X7 receptors [125] activates PANX1, whereas nitric oxide inhibits the channel through S-nitrosylation [126] and PKG-mediated phosphorylation [127]....
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References
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