Pannexin 1-dependent ATP release from venous endothelium promotes acute vascular inflammation (669.8)
Reads0
Chats0
TLDR
Tumor necrosis factor α (TNFα) activates endothelial cells (EC) promoting EC-leukocyte interactions in the venous circulation which is mediated, in part, by purinergic signaling.Abstract:
Tumor necrosis factor α (TNFα) activates endothelial cells (EC) promoting EC-leukocyte interactions in the venous circulation which is mediated, in part, by purinergic signaling. However, it is cur...read more
Citations
More filters
Journal ArticleDOI
Extracellular ATP metabolism on vascular endothelial cells: A pathway with pro-thrombotic and anti-thrombotic molecules.
Eduardo Fuentes,Iván Palomo +1 more
TL;DR: The relative contribution of extracellular ATP metabolism in platelet regulation is explored and it is found that adenine nucleotides in the vascular system are involved in modulating the processes linked to vascular thrombosis exerting various effects in platelets.
Patent
Compositions and methods for regulating leukocyte adhesion
TL;DR: In this paper, the ATP-release channel Pannexin1 (Panx1) opens downstream of EC activation by tumor necrosis factor α (TNF α), which involves activation of Type 1 TNF receptors, recruitment of Src Family Kinases (SFK), and SFK-dependent phosphorylation of Panx1.
Related Papers (5)
A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability
Daniela Maier-Begandt,Daniela Maier-Begandt,Heather Skye Comstra,Samuel A. Molina,Nenja Krüger,Nenja Krüger,Claire A. Ruddiman,Yen Lin Chen,Xiaobin Chen,Lauren A Biwer,Scott R. Johnstone,Alexander W. Lohman,Miranda E. Good,Leon J. DeLalio,Kwangseok Hong,Hannah M. Bacon,Zhen Yan,Swapnil K. Sonkusare,Michael Koval,Brant E. Isakson +19 more