Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae
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TLDR
This report identifies and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor and shows that in V.cholerae these communication systems converge to control virulence.About:
This article is published in Cell.The article was published on 2002-08-09 and is currently open access. It has received 644 citations till now. The article focuses on the topics: Quorum sensing & Vibrio cholerae.read more
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QUORUM SENSING: Cell-to-Cell Communication in Bacteria
TL;DR: This review focuses on the architectures of bacterial chemical communication networks; how chemical information is integrated, processed, and transduced to control gene expression; how intra- and interspecies cell-cell communication is accomplished; and the intriguing possibility of prokaryote-eukaryote cross-communication.
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Phages and the Evolution of Bacterial Pathogens: from Genomic Rearrangements to Lysogenic Conversion
TL;DR: The current review presents the available genomics and biological data on prophages from bacterial pathogens in an evolutionary framework to demonstrate that the chromosomes from bacteria and their viruses (bacteriophages) are coevolving.
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Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control
TL;DR: This work reviews the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae and examines recent efforts to inhibit quorum sensing in these pathogens with the goal of designing novel antimicrobial therapeutics.
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Bacterial Quorum-Sensing Network Architectures
Wai Leung Ng,Bonnie L. Bassler +1 more
TL;DR: It is argued that the Vibrio quorum-sensing systems are optimally designed to precisely translate extracellular autoinducer information into internal changes in gene expression.
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Quorum sensing signal–response systems in Gram-negative bacteria
Kai Papenfort,Bonnie L. Bassler +1 more
TL;DR: This Review examines how features of quorum sensing signal–response systems combine to control collective behaviours in Gram-negative bacteria and the implications for host–microbial associations and antibacterial therapy.
References
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Quorum Sensing in Bacteria
TL;DR: The evolution of quorum sensing systems in bacteria could, therefore, have been one of the early steps in the development of multicellularity.
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The involvement of cell-to-cell signals in the development of a bacterial biofilm
David G. Davies,Matthew R. Parsek,Matthew R. Parsek,Matthew R. Parsek,James P. Pearson,James P. Pearson,James P. Pearson,Barbara H. Iglewski,Barbara H. Iglewski,Barbara H. Iglewski,J. W. Costerton,J. W. Costerton,J. W. Costerton,E. P. Greenberg,E. P. Greenberg,E. P. Greenberg +15 more
TL;DR: The involvement of an intercellular signal molecule in the development of Pseudomonas aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aerug inosaBiofilms are a persistent problem.
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DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
John F. Heidelberg,Jonathan A. Eisen,William C. Nelson,Rebecca A. Clayton,Michelle L. Gwinn,Robert J. Dodson,Daniel H. Haft,Erin Hickey,Jeremy Peterson,Lowell Umayam,Steven R. Gill,Karen E. Nelson,Timothy D. Read,Hervé Tettelin,Delwood Richardson,Maria D. Ermolaeva,Jessica Vamathevan,Steven Bass,Haiying Qin,Ioana Dragoi,Patrick Sellers,Lisa McDonald,Teresa Utterback,Robert D. Fleishmann,William C. Nierman,Owen White,Steven L. Salzberg,Hamilton O. Smith,Rita R. Colwell,Rita R. Colwell,John J. Mekalanos,J. Craig Venter,Claire M. Fraser +32 more
TL;DR: The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.
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Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products
TL;DR: The concept of cloning the metagenome to access the collective genomes and the biosynthetic machinery of soil microflora is explored here.
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Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
Kay H. McClean,Michael K. Winson,Leigh Fish,Adrian Taylor,Siri Ram Chhabra,Miguel Cámara,Mavis Daykin,John H. Lamb,Simon Swift,Barrie W. Bycroft,Gordon S. A. B. Stewart,Paul Williams +11 more
TL;DR: The ability of CV026 to respond to a series of synthetic AHL and N-acylhomocysteine thiolactone (AHT) analogues is explored, greatly extending the ability to detect a wide spectrum of AHL signal molecules.