Partial transition-state inhibitors of glyoxalase I from human erythrocytes, yeast and rat liver.
TL;DR: In this study a number of inhibitors of glyoxalase I are described which were designed based on the enediol moiety of this reactive intermediate and can be described as partial transition-state analogues.
About: This article is published in Biochimica et Biophysica Acta.The article was published on 1985-05-20. It has received 23 citations till now. The article focuses on the topics: Lactoylglutathione lyase & Glutathione.
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TL;DR: A study of a series of S-alkylglutathiones as inhibitors of the enzyme, glyoxalase I, revealed that a non-polar region exists on the enzyme which plays an important role in the formation of an enzyme-inhibitor complex.
105 citations
TL;DR: Glyoxalase I from human and porcine erythrocytes, rat liver, and yeast was shown to contain zinc in a stoichiometry of about 1 mole per mole of enzyme subunit.
93 citations