Figure 1. Blood circulation half-lives and biodistribution. (a) ΔR1 (=1/T1,post 1/T1,pre) of all blood samples, as measured at 9.4 T, plotted vs time after injection. Blood circulation half-lives were determined by fitting with a mono-exponential decay function (solid lines), leading to the blood circulation half-lives (t1/2) as shown in the table (Mean SD). (b) Biodistribution of nanoparticles in several organs. The red color originates from the near-infrared (NIR) signal of micelles and liposomes. As a non-fluorescent negative control, organs from mice injected with Gd–DTPA are shown. Scale bar = 100mm.
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