Journal ArticleDOI
Pathogenesis and bisphosphonate treatment of skeletal events and bone pain in metastatic cancer: focus on ibandronate.
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TLDR
The nitrogencontaining bisphosphonate, ibandronate, has been shown to reduce the risk of skeletal events after oral or intravenous administration in controlled clinical trials in various malignancies, and to confer significant palliation of bone pain and improvements in health-related quality of life in patients with metastatic breast cancer, in particular.Abstract:
Bone metastases are the most common cause of pain in patients with advanced cancer, and are associated with progressive skeletal destruction, spinal problems, and hypercalcaemia. Radiotherapy, analgesia, and surgery are the accepted treatment options for chronic malignant bone pain, with a stepped approach being generally recommended. In the past decade, the bisphosphonates, which reduce bone turnover, increase bone mass, and decrease the risk of fracture, have become established as an effective treatment in patients with cancer metastasising to bone. The nitrogencontaining bisphosphonate, ibandronate, has been shown to reduce the risk of skeletal events after oral or intravenous administration in controlled clinical trials in various malignancies, and to confer significant palliation of bone pain and improvements in health-related quality of life in patients with metastatic breast cancer, in particular. Tolerability of this agent has been good, with very low frequencies of acute-phase reactions and osteonecrosis of the jaw, and no evidence of acute nephrotoxicity.read more
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The function of the vertebral veins and their role in the spread of metastases : Skeletal cancer metastasis recent expansion of orthopaedic expertise
TL;DR: The dissemination of infections and tumors from organs in other regions by the veins about the spine has also been considered, leading to a better appreciation of the role of the vertebral veins in normal physiology.
Journal ArticleDOI
Vascular action of bisphosphonates: In vitro effect of alendronate on the regulation of cellular events involved in vessel pathogenesis.
TL;DR: The hypothesis that ALN is an active drug at vascular level that regulates key processes involved in vascular pathogenesis through a direct action on vessel cells is supported.
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A multicenter, retrospective epidemiologic survey of the clinical features and management of bone metastatic disease in China.
Yunpeng Yang,Yuxiang Ma,Jin Sheng,Yan Huang,Yuanyuan Zhao,Wenfeng Fang,Shaodong Hong,Ying Tian,Cong Xue,Li Zhang +9 more
TL;DR: It is suggested that prompt and persistent BP treatment was associated with a reduced risk of SREs and that the proper application of BP was not as common as expected in China.
Journal ArticleDOI
Expert consensus on the diagnosis and treatment of bone metastasis in lung cancer (2014 version)
Yan Sun,Zhongzhen Guan,Meilin Liao,Xin Yu,Changli Wang,Jie Wang,Xiaohui Niu,Yuankai Shi,Xiuyi Zhi,Yunpeng Liu,Mengzhong Liu,Yiping Zhang,Yue Yang,Jingnan Shen,Gongyan Chen,Qinghua Zhou,Caicun Zhou,Qisen Guo,Lili Tang,Jianchun Duan,Jun Liang,Yingjian Zhang,Ying Cheng +22 more
TL;DR: Expert Consensus on the Diagnosis and Treatment of Bone Metastasis in Lung Cancer (2014 version)
Journal ArticleDOI
Bisphosphonate-related osteonecrosis of the jaw: an Italian post-marketing surveillance analysis
Elisabetta Parretta,Laura Sottosanti,Liberata Sportiello,Concetta Rafaniello,Simona Potenza,Salvatore D'Amato,Rocio González-González,Francesco Rossi,Giuseppe Colella,Annalisa Capuano +9 more
TL;DR: This study shows that BRONJ can occur much earlier than hitherto reported, adds new data on BRonJ onset following ibandronate treatment and reveals that patients who cease BP-based therapy develop ONJ, raising the question of post-treatment monitoring strategies.
References
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Journal Article
Pain assessment: Global use of the Brief Pain Inventory.
Charles S. Cleeland,Ryan Km +1 more
TL;DR: The development of the Brief Pain Inventory and the various applications to which the BPI is suited are described, being adopted in many countries for clinical pain assessment, epidemiological studies, and in studies of the effectiveness of pain treatment.
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Mechanisms of bone metastasis.
TL;DR: Bone metastasis causes severe bone pain and can result in fractures without any injury, as well as other life-threatening conditions, and patients with prostate cancer who usually have bone metastasis that shows increased new bone formation also have increased bone destruction in the same lesions.
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The function of the vertebral veins and their rôle in the spread of metastases
TL;DR: In this paper, the authors examined the role of the vertebral veins in normal physiology and found that the distribution of these paradoxic metastases is not at all that of the nerve sheaths of the area as suggested by Warren et al.
Journal ArticleDOI
Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
TL;DR: Clinical trials are exploring the effects of denosumab, a fully human anti-RANKL antibody, on bone loss in patients with osteoporosis, bone metastasis, myeloma, and rheumatoid arthritis.
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Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer.
Alexander H.G. Paterson,Trevor J. Powles,John A. Kanis,Eugene V. McCloskey,J. Hanson,Stanley W. Ashley +5 more
TL;DR: Findings indicate that oral clodronate has a beneficial effect on the skeletal morbidity associated with breast cancer and should be considered as antiosteolytic therapy in affected patients.