Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
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Cites background from "Pathogenesis of Human Systemic Lupu..."
...SLE is a prototypical chronic systemic autoimmune disease afflicting women in the childbearing years and can affect any organ in the body (10, 11)....
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References
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"Pathogenesis of Human Systemic Lupu..." refers background in this paper
...1Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA 2Department of Rheumatology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA 3Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan *Correspondence: vmoulton@bidmc.harvard.edu (V.R. Moulton) and gtsokos@bidmc.harvard.edu (G.C. Tsokos)....
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...Currently, the diagnosis, which is frequently difficult and delayed, is based on established criteria by the American College of Rheumatology [2] and the treatment is still limited to the use of general immunosuppressive drugs....
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...Although the American College of Rheumatology criteria are used to diagnose the disease, it is abundantly clear that SLE is not a single disease/pathology....
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"Pathogenesis of Human Systemic Lupu..." refers background in this paper
...pDCs produce large amounts of type I IFN, and this IFN-a/b ‘signature’ is often observed in SLE patients [18]....
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...Transcriptomics refers to the analysis of gene expression at a global level, and microarrays have helped to explore aberrantly regulated genes in peripheral blood mononuclear cells (PBMCs) taken from SLE patients relative to healthy controls [18,19]....
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1,873 citations
"Pathogenesis of Human Systemic Lupu..." refers background in this paper
...These defects play vital roles in the pathogenesis of SLE, including ineffective apoptotic debris clearance [96], self-antigen presentation [92], and inflammatory cytokine production [19,94,97] (Figure 3)....
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...Transcriptomics refers to the analysis of gene expression at a global level, and microarrays have helped to explore aberrantly regulated genes in peripheral blood mononuclear cells (PBMCs) taken from SLE patients relative to healthy controls [18,19]....
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