Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Citations
20,189 citations
4,408 citations
Cites background from "Pathological findings of COVID-19 a..."
...Of note, interstitial mononuclear inflammatory infiltrates in heart tissue has 32 The level and duration of infectious virus replication are important factors in assessing the risk of trans mission and guiding decisions regarding isolation of patients....
[...]
3,488 citations
Cites background or result from "Pathological findings of COVID-19 a..."
...In this study, although decreased numbers of CD8+ T cells were detected in severe cases, the proportion of CD8+HLA-DR+ T cells was slightly greater than that in moderate cases, which is in agreement with a recent case report (16)....
[...]
...Severe cases: Meeting any of the following — respiratory distress, respiratory rate ≥ 30 breaths/min; SpO2 ≤ 93% at rest; and PaO2/FIO2 ≤ were found to harbor high concentrations of cytotoxic granule components, including perforin and granulysin (16)....
[...]
...Furthermore, a cytokine storm was exhibited in nearly all these populations; the only currently available histological examination of a severe case who died of SARS-CoV-2 demonstrated lung interstitial mononuclear inflammatory infiltrates, dominated by lymphocytes, and multinucleated syncytial cells with atypical enlarged pneumocytes in the intra-alveolar spaces (16)....
[...]
3,371 citations
3,360 citations
Cites background or methods from "Pathological findings of COVID-19 a..."
...The duration of hospitalization before testing was longer in patients with cardiac injury than those without cardiac injury (median [range] time, 3 [1-15] days vs 2 [1-8] days; P < ....
[...]
...Distribution of hs-TNI based on detection time from hospitalization (median [IQR], 2 [1-15] days) is shown in eFigure 1 in the Supplement....
[...]
References
36,578 citations
9,231 citations
7,392 citations
660 citations
332 citations