Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal
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5,329 citations
Cites background from "Pathophysiological Mechanisms of At..."
...Pathophysiological changes as a consequence of atrial fibrillation After the onset of AF, changes of atrial electrophysiological properties, mechanical function, and atrial ultrastructure occur with different time courses and with different pathophysiological consequences.(18) Shortening of the atrial effective refractory period within the first days of AF has been documented in humans....
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5,255 citations
Cites background from "Pathophysiological Mechanisms of At..."
...AF has many different drivers, which are only partially targeted by antiarrhythmic drugs or catheter ablation [96]....
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References
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"Pathophysiological Mechanisms of At..." refers background in this paper
...in 1998 (217) has renewed the interest in “focal” sources of AF....
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...(217) were the first to demonstrate that repetitive activity with a very short cycle length may occur in the PVs, and that radiofrequency ablation of such drivers can be used to treat AF....
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...A sizeable portion of patients with lone AF suffer from “focal AF” that is initiated by triggers that can be localized to preferential sites, mainly the pulmonary veins (PV) (217)....
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5,329 citations
4,498 citations
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