Pathway analysis of primary central nervous system lymphoma
Han W. Tun,David Personett,Karen A. Baskerville,David M. Menke,Kurt A. Jaeckle,Pamela A. Kreinest,Brandy Edenfield,Abba C. Zubair,Brian P. O'Neill,Weil R. Lai,Peter J. Park,Michael McKinney +11 more
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TLDR
The gene expression signature discovered in this study may represent a true "CNS signature" because it contrasted PCNSL with wide-spectrum non-CNS DLBCL on a genomic scale and performed an in-depth bioinformatic analysis.About:
This article is published in Blood.The article was published on 2008-03-15 and is currently open access. It has received 154 citations till now. The article focuses on the topics: Primary central nervous system lymphoma.read more
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The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
The 2008 WHO classification of lymphomas: implications for clinical practice and translational research
TL;DR: The 4(th) edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues published in 2008 builds upon the success of the 2001 3(rd) edition; new entities are defined, and solutions for problematic categories are sought.
Journal ArticleDOI
Primary Vitreoretinal Lymphoma: A Report from an International Primary Central Nervous System Lymphoma Collaborative Group Symposium
Chi-Chao Chan,James L. Rubenstein,Sarah E. Coupland,Janet L. Davis,J. William Harbour,Patrick B. Johnston,Nathalie Cassoux,Nathalie Cassoux,Valérie Touitou,Justine R. Smith,Tracy T. Batchelor,Jose S. Pulido +11 more
TL;DR: Because of the disease rarity, international, multicenter, collaborative efforts are required to better understand the biology and pathogenesis of PVRL as well as to define both diagnostic markers and optimal therapies.
Journal ArticleDOI
Discoidin domain receptor tyrosine kinases: new players in cancer progression.
TL;DR: This review summarizes and discusses the current knowledge on DDR expression and function in cancer, and hopes that this effort will encourage more research into these poorly understood but unique RTKs, which have the potential of becoming novel therapeutic targets in cancer.
Journal ArticleDOI
Recurrent Mutations of MYD88 and TBL1XR1 in Primary Central Nervous System Lymphomas
Alberto González-Aguilar,Ahmed Idbaih,Blandine Boisselier,Naima Habbita,Marta Rossetto,Alice Laurenge,Aurelie Bruno,Anne Jouvet,Marc Polivka,Clovis Adam,Dominique Figarella-Branger,Catherine Miquel,Anne Vital,Hervé Ghesquières,Remy Gressin,Vincent Delwail,Luc Taillandier,Olivier Chinot,Pierre Soubeyran,Emmanuel Gyan,Sylvain Choquet,Caroline Houillier,Carole Soussain,Marie Laure Tanguy,Yannick Marie,Karima Mokhtari,Khê Hoang-Xuan +26 more
TL;DR: This study provides new insights into the molecular tumorigenesis of PCNSL and identifies novel genetic alterations in this disease, especially MYD88 and TBL1XR1 mutations activating the NF-κB signaling pathway, which may be promising targets for future therapeutic strategies.
References
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Cluster analysis and display of genome-wide expression patterns
TL;DR: A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function.
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Missing value estimation methods for DNA microarrays.
Olga G. Troyanskaya,Michael N. Cantor,Gavin Sherlock,Patrick O. Brown,Trevor Hastie,Robert Tibshirani,David Botstein,Russ B. Altman +7 more
TL;DR: It is shown that KNNimpute appears to provide a more robust and sensitive method for missing value estimation than SVDimpute, and both SVD Impute and KNN Impute surpass the commonly used row average method (as well as filling missing values with zeros).
Journal ArticleDOI
The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma
Andreas Rosenwald,George E. Wright,Wing C. Chan,Wing C. Chan,Joseph M. Connors,Elias Campo,Richard I. Fisher,Randy D. Gascoyne,H. Konrad Muller-Hermelink,Erlend B. Smeland,Jena M. Giltnane,Elaine M. Hurt,Hong Zhao,Lauren Averett,Liming Yang,Wyndham H. Wilson,Elaine S. Jaffe,Richard M. Simon,Richard D. Klausner,John Powell,P L Duffey,Dan L. Longo,Timothy C. Greiner,Dennis D. Weisenburger,Warren G. Sanger,Bhavana J. Dave,James C. Lynch,Julie M. Vose,James O. Armitage,Emilio Montserrat,Armando López-Guillermo,Thomas M. Grogan,Thomas P. Miller,Michel Leblanc,German Ott,Stein Kvaløy,Jan Delabie,Harald Holte,Peter Krajci,Trond Stokke,Louis M. Staudt +40 more
TL;DR: DNA microarrays can be used to formulate a molecular predictor of survival after chemotherapy for diffuse large-B-cell lymphoma and this gene-based predictor and the international prognostic index were independent prognostic indicators.
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Function and biological roles of the Dickkopf family of Wnt modulators
TL;DR: Dickkopf genes comprise an evolutionary conserved small gene family of four members and a unique Dkk3-related gene, Dkkl1 (soggy), which encode secreted proteins that typically antagonize Wnt/β-catenin signaling, by inhibiting the Wnt coreceptors Lrp5 and 6.
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The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.
Dorothee Chabas,Sergio E. Baranzini,Dennis J. Mitchell,Claude C.A. Bernard,Susan R. Rittling,David T. Denhardt,Raymond A. Sobel,Christopher Lock,Marcela Karpuj,Marcela Karpuj,Rosetta Pedotti,Renu A. Heller,Jorge R. Oksenberg,Lawrence Steinman +13 more
TL;DR: Osteopontin appears to regulate T helper cell–1 (TH1)–mediated demyelinating disease, and it may offer a potential target in blocking development of progressive MS.
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