Pathways towards and away from Alzheimer's disease
Citations
8,448 citations
Cites background from "Pathways towards and away from Alzh..."
...The leading hypothesis about the cause of AD proposes that toxic forms of the amyloid ß protein (Aß) initiate a cascade of events ending in synaptic dysfunction and cell death (Walsh & Selkoe 2004, Mattson 2004)....
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2,569 citations
Cites background from "Pathways towards and away from Alzh..."
...AD is associated with the pathological accumulation of misfolded proteins, including amyloid- (A ) (Mattson, 2004; Walsh and Selkoe, 2004)....
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1,790 citations
1,589 citations
1,319 citations
Cites background from "Pathways towards and away from Alzh..."
...which are abundant numbers of “plaques” and “tangles” by postmortem examination [85]....
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References
4,110 citations
"Pathways towards and away from Alzh..." refers background in this paper
...Subsequent linkage analysis identified a region of chromosome 14 as the locus of a mutation(s) responsible for inherited AD in several different pedigrees, and the presenilin-1 (PS1) gene was identified as the affected gen...
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4,031 citations
3,811 citations
3,608 citations
3,362 citations
"Pathways towards and away from Alzh..." refers background in this paper
...Evidence for participation of cell- and antibody-mediated responses in AD pathogenesis comes from recent studies demonstrating the ability of the immune system to generate antibodies against Aβ that may promote removal of Aβ from the brai...
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