Journal ArticleDOI
Patients Treated with Catheter Ablation for Atrial Fibrillation Have Long-Term Rates of Death, Stroke, and Dementia Similar to Patients Without Atrial Fibrillation
T. Jared Bunch,Brian G. Crandall,J. Peter Weiss,M.S.P.H. Heidi T. May Ph.D.,Tami L Bair,Jeffrey S. Osborn,Jeffrey L. Anderson,Joseph B. Muhlestein,M.P.H. Benjamin D. Horne Ph.D.,Donald L. Lappe,John D. Day +10 more
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TLDR
The long‐term impact of AF ablation on mortality, heart failure (HF), stroke, stroke, and dementia in a large system‐wide patient population is evaluated.Abstract:
Introduction Atrial fibrillation (AF) adversely impacts mortality, stroke, heart failure, and dementia. AF ablation eliminates AF in most patients. We evaluated the long-term impact of AF ablation on mortality, heart failure (HF), stroke, and dementia in a large system-wide patient population. Methods A total of 4,212 consecutive patients who underwent AF ablation were compared (1:4) to 16,848 age/gender matched controls with AF (no ablation) and 16,848 age/gender matched controls without AF. Patients were enrolled from the large ongoing prospective Intermountain AF study and were followed for at least 3 years. Results Of the 37,908 patients, mean age 65.0 ± 13 years, 5,667 (14.9%) died, 1,296 (3.4%) had a stroke, and 1,096 (2.9%) were hospitalized for HF over >3 years of follow-up. AF ablation patients were less likely to have diabetes, but were more likely to have hypertension, HF, and significant valvular heart disease. AF ablation patients had a lower risk of death and stroke in comparison to AF patients without ablation. Alzheimer's dementia occurred in 0.2% of the AF ablation patients compared to 0.9% of the AF no ablation patients and 0.5% of the no AF patients (P Conclusions AF ablation patients have a significantly lower risk of death, stroke, and dementia in comparison to AF patients without ablation. AF ablation may eliminate the increased risk of death and stroke associated with AF.read more
Citations
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2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS).
Gerhard Hindricks,Tatjana S. Potpara,Nikolaos Dagres,Elena Arbelo,Jeroen J. Bax,Carina Blomström-Lundqvist,Giuseppe Boriani,Manuel Castellá,Gheorghe Andrei Dan,Polychronis Dilaveris,Laurent Fauchier,Gerasimos Filippatos,Jonathan M. Kalman,Jonathan M. Kalman,Mark La Meir,Deirdre A. Lane,Jean-Pierre Lebeau,Maddalena Lettino,G. Y. H. Lip,Fausto J. Pinto,G. Neil Thomas,Marco Valgimigli,Isabelle C. Van Gelder,Isabelle C. Van Gelder,Bart P. Van Putte,Caroline L Watkins +25 more
TL;DR: The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only and no commercial use is authorized.
Journal ArticleDOI
2017 HRS / EHRA / ECAS / APHRS / SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
Hugh Calkins,Gerhard Hindricks,Riccardo Cappato,Young Hoon Kim,Eduardo B. Saad,Luis Aguinaga,Joseph G. Akar,Vinay Badhwar,Josep Brugada,John Camm,Peng Sheng Chen,Shih Ann Chen,Mina K. Chung,Jens Cosedis Nielsen,Anne B. Curtis,D. Wyn Davies,John D. Day,Andre d'Avila,N. M. S. de Groot,Luigi Di Biase,Mattias Duytschaever,James R. Edgerton,Kenneth A. Ellenbogen,Patrick T. Ellinor,Sabine Ernst,Guilherme Fenelon,Edward P. Gerstenfeld,David E. Haines,Michel Haïssaguerre,Robert H. Helm,Elaine M. Hylek,Warren M. Jackman,José Jalife,José Jalife,Jonathan M. Kalman,Josef Kautzner,Hans Kottkamp,Karl Heinz Kuck,Koichiro Kumagai,Richard Lee,Thorsten Lewalter,Bruce D. Lindsay,Laurent Macle,Moussa Mansour,Francis E. Marchlinski,Gregory F. Michaud,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Ken Okumura,Douglas L. Packer,Evgeny Pokushalov,Matthew R. Reynolds,Prashanthan Sanders,Mauricio Scanavacca,Richard J. Schilling,Claudio Tondo,Hsuan Ming Tsao,Atul Verma,David J. Wilber,Teiichi Yamane +60 more
TL;DR: This 2017 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a writing group, convened by these five international societies.
Journal ArticleDOI
Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial
Douglas L. Packer,Daniel B. Mark,Richard A. Robb,Kristi H. Monahan,Tristram D. Bahnson,Jeanne E. Poole,Peter A. Noseworthy,Yves Rosenberg,Neal Jeffries,L. Brent Mitchell,Greg C. Flaker,Evgeny Pokushalov,Alexander Romanov,T. Jared Bunch,Georg Noelker,Ardashev Av,Amiran Revishvili,David J. Wilber,Riccardo Cappato,Karl-Heinz Kuck,Gerhard Hindricks,D. Wyn Davies,Peter R. Kowey,Gerald V. Naccarelli,James A. Reiffel,Jonathan P. Piccini,Adam P. Silverstein,Hussein R. Al-Khalidi,Kerry L. Lee +28 more
TL;DR: Among patients with AF, the strategy of catheter ablation, compared with medical therapy, did not significantly reduce the primary composite end point of death, disabling stroke, serious bleeding, or cardiac arrest, which should be considered in interpreting the results of the trial.
Journal ArticleDOI
Early Rhythm-Control Therapy in Patients with Atrial Fibrillation
Paulus Kirchhof,A. John Camm,Andreas Goette,Axel Brandes,Lars Eckardt,Arif Elvan,Thomas Fetsch,Isabelle C. van Gelder,Doreen Haase,Laurent M. Haegeli,Frank Hamann,Hein Heidbuchel,Gerhard Hindricks,Josef Kautzner,Karl-Heinz Kuck,Lluís Mont,G. André Ng,Jerzy Rekosz,Norbert Schoen,Ulrich Schotten,Anna Suling,Jens Taggeselle,Sakis Themistoclakis,Eik Vettorazzi,Panos Vardas,Karl Wegscheider,Stephan Willems,Harry J. Crijns,Günter Breithardt +28 more
TL;DR: Early rhythm-control therapy was associated with a lower risk of cardiovascular outcomes than usual care among patients with early atrial fibrillation and cardiovascular conditions.
Journal ArticleDOI
Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies
Kay Deckers,Martin P.J. van Boxtel,Olga J. G. Schiepers,Marjolein E. de Vugt,Juan Luis Muñoz Sánchez,Kaarin J. Anstey,Carol Brayne,Jean-François Dartigues,Knut Engedal,Miia Kivipelto,Karen Ritchie,John M. Starr,Kristine Yaffe,Kate Irving,Frans R.J. Verhey,Sebastian Köhler +15 more
TL;DR: The goal of this paper is to identify the major modifiable risk factors for dementia as a first step in developing an effective preventive strategy and promoting healthy late life cognitive functioning.
References
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Journal ArticleDOI
A comparison of rate control and rhythm control in patients with atrial fibrillation.
D. G. Wyse,Albert L. Waldo,John P. DiMarco,Michael J. Domanski,Yves Rosenberg,Eleanor Schron,Joyce C Kellen,H L Greene,M C Mickel,J E Dalquist,Scott D. Corley +10 more
TL;DR: Management of atrial fibrillation with the rhythm-control strategy offers no survival advantage over the rate- control strategy, and there are potential advantages, such as a lower risk of adverse drug effects, with the rate -control strategy.
Journal ArticleDOI
Secular Trends in Incidence of Atrial Fibrillation in Olmsted County, Minnesota, 1980 to 2000, and Implications on the Projections for Future Prevalence
Yoko Miyasaka,Marion E. Barnes,Bernard J. Gersh,Stephen S. Cha,Kent R. Bailey,Walter P. Abhayaratna,James B. Seward,Teresa S.M. Tsang +7 more
TL;DR: The age-adjusted incidence of AF increased significantly in Olmsted County during 1980 to 2000 and the projected number of persons with AF for the United States will exceed 10 million by 2050, underscoring the urgent need for primary prevention strategies against AF development.
Journal ArticleDOI
A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation
Isabelle C. Van Gelder,VE Hagens,Hans A. Bosker,J. Herre Kingma,Otto Kamp,T Kingma,Salah A. Said,Julius I. Darmanata,Alphons J.M. Timmermans,Jan G.P. Tijssen,Harry J.G.M. Crijns +10 more
TL;DR: Rate control is not inferior to rhythm control for the prevention of death and morbidity from cardiovascular causes and may be appropriate therapy in patients with a recurrence of persistent atrial fibrillation after electrical cardioversion.
Journal ArticleDOI
A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study.
TL;DR: In this article, the effect of atrial fibrillation on long-term morbidity and mortality was described, and Cox proportional hazards models were used to adjust for age and cardiovascular conditions.
Journal ArticleDOI
Rhythm control versus rate control for atrial fibrillation and heart failure
Denis Roy,Mario Talajic,Stanley Nattel,D. George Wyse,Paul Dorian,Kerry L. Lee,Martial G. Bourassa,J. Malcolm,O. Arnold,Alfred E. Buxton,A. John Camm,Stuart J. Connolly,Marc Dubuc,Anique Ducharme,Peter G. Guerra,Stefan H. Hohnloser,Jean Lambert,Jean-Yves Le Heuzey,Ole Pedersen,Jean-Lucien Rouleau,Bramah N. Singh,Lynne W. Stevenson,William G. Stevenson,Bernard Thibault,Albert L. Waldo +24 more
TL;DR: In patients with atrial fibrillation and congestive heart failure, a routine strategy of rhythm control does not reduce the rate of death from cardiovascular causes, as compared with a rate-control strategy.