Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer
Hyung Seok Park,Shin-Hyuk Kim,Ki-Ho Kim,Ho Yoo,Byung Joo Chae,Ja Seong Bae,Byung Joo Song,Sang Seol Jung +7 more
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TLDR
Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer may be considered, and organ-specific metastasis may depend on the Molecular subtype of breast cancer.Abstract:
Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer. In an investigation of 313 women with breast cancer who underwent surgery from 1994 and 2000, the expressions of estrogen and progestrone receptor (ER/PR), and human epithelial receptor-2 (HER2) were evaluated. The subtypes were defined as luminal-A, luminal-HER2, HER2-enriched, and triple negative breast cancer (TNBC) according to ER, PR, and HER2 status. Bone was the most common site of distant recurrence. The incidence of first distant recurrence site was significantly different among the subtypes. Brain metastasis was more frequent in the luminal-HER2 and TNBC subtypes. In subgroup analysis, overall survival in patients with distant recurrence after 24 months after surgery was significantly different among the subtypes. Organ-specific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer may be considered.read more
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Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study
TL;DR: The pathological subtypes of breast cancer are clearly different in metastatic behavior with regard to the sites of distant metastasis, emphasizing that this knowledge may help to determine the appropriate strategy for follow-up and guide personalized medicine.
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The Clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancer
TL;DR: Stage IV breast cancer patients have different clinicopathological characteristics and survival outcomes according to different metastatic sites, and patients with bone metastasis have the best prognosis, and brain metastasis is the most aggressive subgroup.
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Metastatic patterns of breast cancer subtypes: What radiologists should know in the era of personalized cancer medicine
Sona A. Chikarmane,Sona A. Chikarmane,Sree Harsha Tirumani,Sree Harsha Tirumani,Stephanie A. Howard,Stephanie A. Howard,Jyothi P. Jagannathan,Jyothi P. Jagannathan,Pamela J. DiPiro,Pamela J. DiPiro +9 more
TL;DR: It is important for radiologists to understand the nuances of these breast cancer subtypes to predict metastatic behaviours and guide possible imaging surveillance.
Journal ArticleDOI
The prognosis analysis of different metastasis pattern in patients with different breast cancer subtypes: a SEER based study.
TL;DR: It was proven that only bone metastasis was not a prognostic factor in the HR+/HER2-, HR+ /HER2+ and HR-/her2+ subgroup, and patients with brain metastasis had the worst cancer specific survival (CSS) in all the subgroups of BCS.
Journal ArticleDOI
Pattern of Local Recurrence and Distant Metastasis in Breast Cancer By Molecular Subtype
Xingrao Wu,Ayesha Baig,Goulnar Kasymjanova,Kamran Kafi,Christina Holcroft,Hind Mekouar,Annie Carbonneau,Boris Bahoric,Khalil Sultanem,Thierry Muanza +9 more
TL;DR: Of the four subtypes, the LA subtype tends to have the best prognosis, fairly high survival, and low recurrent or metastases rates, and a statistically significant association between survival and molecular subtypes in an univariate analysis is demonstrated.
References
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K. David Voduc,Maggie C.U. Cheang,Scott Tyldesley,Karen A. Gelmon,Torsten O. Nielsen,Hagen F. Kennecke +5 more
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Marcel Smid,Yixin Wang,Yi Zhang,Anieta M. Sieuwerts,Jack C. Yu,Jan G. M. Klijn,John A. Foekens,John W.M. Martens +7 more
TL;DR: The five major molecular subtypes in breast cancer are evidently different with regard to their ability to metastasize to distant organ(s), and share biological features and pathways with their preferred distant metastatic site.
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TL;DR: Women with HER‐2 overexpressing metastatic breast carcinoma benefit from trastuzumab‐based therapy, but trastzumab does not cross the blood‐brain barrier, and central nervous system (CNS) disease in these women is characterized.
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Nan Lin,Elizabeth B. Claus,Elizabeth B. Claus,Jessica Sohl,Abdul Rab Razzak,Amal Arnaout,Eric P. Winer +6 more
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