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Journal ArticleDOI

Pattern of drug use in the management of psoriasis in a tertiary care hospital: a prospective study

01 Jan 2014-International journal of basic and clinical pharmacology (Medip Academy)-Vol. 3, Iss: 4, pp 611-618

TL;DR: The topical medications induced effective resolution of lesions in most of the patients, along with adequate symptomatic relief, and regular follow-up is required not only to monitor the treatment response, but also to ensure good patient compliance by proper counseling.

AbstractBackground: Psoriasis is a chronic skin disease, characterized by chronic and recurrent scaly plaques with itching. The treatment modalities for psoriasis include topical, systemic, and phototherapy (PT). The pattern of therapy may vary depending upon the type, severity, and duration of the disease. As there are few reports in the Indian literature regarding the pattern of drug use in psoriasis and evaluating the efficacy and patient compliance to treatment, the present study was conducted. Methods: This was a prospective, observational study conducted on121 newly diagnosed and untreated patients with psoriasis, who attended Dermatology outpatient department of a tertiary care hospital. The severity of the disease was assessed by baseline psoriasis area severity index (PASI) score. Most of the patients were treated with topical therapy consisting of glucocorticoids (GC) monotherapy or combination with, salicylic acid, calcitriol and coal tar. Systemic therapy and PT were considered only for severe cases of psoriasis with baseline PASI score >4. The patients were monitored every 2 weeks for 3 months. Results: The topical medications induced effective resolution of lesions in most of the patients, along with adequate symptomatic relief. The response to GC monotherapy was found significant (90.47%; p 4. Regular follow-up is required not only to monitor the treatment response, but also to ensure good patient compliance by proper counseling.

Topics: Psoriasis (60%), Outpatient clinic (55%), Symptomatic relief (54%)

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Journal ArticleDOI
TL;DR: The differences among clinical varieties in their presenting features, severity, natural course, and response to the treatment are responsible for variation in choice of therapy.
Abstract: Background: Psoriasis is a chronic relapsing disease necessitates long-term therapy. The disease severity, comorbidities, and access to health care determine the choice of therapy for psoriasis. The main aim of the treatment of psoriasis is to induce prolonged remission and suppress the disease as there is no cure. It is only palliative and symptomatic treatment, and the choice of treatment modality is according to the type of presentation. The various modalities of treatment available include topical therapies, systemic therapies, phototherapy, and biologics. The difference includes among clinical varieties in their presenting features, severity, natural course, and response to the treatment are responsible for variation in choice of therapy.Methods: In this descriptive study, data collected from patients diagnosed with psoriasis who were admitted in a K.S. Hegde Charitable hospital from January 2017 to January 2019 were analysed for demographic features, disease pattern and drug use pattern in patients.Results: Psoriasis vulgaris/plaque type of psoriasis was commonly observed type of psoriasis in our patients with fourth and fifth decade patients getting more affected. Diabetes was the most commonly associated comorbid disorder. The patients were treated both with systemic and topical modalities of treatment, antihistaminic and methotrexate were most commonly most commonly used systemic drug and moisturizers and glucocorticoids were used topical drugs.Conclusions: Psoriasis needs a multimodality treatment with careful monitoring for the comorbid disorder. Treatment choice is individualised depending on the severity and body parts affected.

2 citations


References
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Book
01 Jan 2014
TL;DR: This 38th edition of Martindale has been completely redesigned to ensure ease of use and greatly improved readability.
Abstract: Martindale: The Complete Drug Reference provides unbiased, evaluated information on drugs and medicines in use around the world. It is updated by an experienced team of pharmacists and life scientists who use their professional expertise to provide an unbiased and evaluated digest of the available literature, selecting the most clinically relevant and appropriate information from reliable published sources. This 38th edition of Martindale has been completely redesigned to ensure ease of use and greatly improved readability. This latest edition contains over 6000 monographs, including 200 new monographs, on drugs and ancillary substances such as herbals, pharmaceutical excipients, and toxins and poisons. There are over 180,000 preparations giving details of preparation name, manufacturer, ingredients, and uses for proprietary preparations and now covering over 40 countries and regions, including China. The content is evidence-based and extensively referenced with links to the published literature.

883 citations


Journal ArticleDOI
TL;DR: The epidemiology of Psoriasis in the General Practice Research Database population is similar to that of other epidemiologic studies of psoriasis performed in the United Kingdom, the United States, and other Western countries.
Abstract: Objective To measure the prevalence and treatment of psoriasis in the United Kingdom. Design Cross-sectional study to determine prevalence and cohort study to determine treatment patterns. Setting Outpatient practices of general practitioners. Patients We included in the analysis all patients who were registered with a general practitioner in the General Practice Research Database from 1987 to 2002. Main Outcome Measures The prevalence and treatment of psoriasis. Results We identified 114 521 patients with psoriasis of a total population of 7 533 475 patients, yielding a prevalence of 1.5%. The prevalence of psoriasis increases more rapidly in young female patients compared with young male patients and declines significantly in patients 70 years and older, regardless of sex. Overall, 91.8% of patients with a diagnosis of psoriasis received a prescription for psoriasis treatment on or after the date of their first diagnostic code of psoriasis in the General Practice Research Database. Most of the patients (55.2%) received only 1 or 2 prescriptions for psoriasis in the first year after psoriasis was documented in the General Practice Research Database. Conclusions The epidemiology of psoriasis in the General Practice Research Database population is similar to that of other epidemiologic studies of psoriasis performed in the United Kingdom, the United States, and other Western countries. Psoriasis carries a substantial burden given its high prevalence and its associated need for prescription therapy. Additional studies are necessary to determine why the prevalence of psoriasis increases more rapidly in female patients and to determine why the prevalence decreases in patients 70 years and older.

547 citations


Journal ArticleDOI
TL;DR: By imposing methodologic control and a numerate approach, epidemiology can offer a major contribution to understand psoriasis.
Abstract: The prevalence of psoriasis is relatively high in the general population, ranging between 0.6% and 4.8%, mainly as a result of chronicity and the absence of a cure. Although genetic-environmental interaction has been proposed as a model for the causation of psoriasis, the evidence for environmental factors is rather scarce. Risk factors, which have been documented in epidemiological studies include smoking, alcohol consumption, diet, infection, drugs, and stressful life events. Psoriasis affects the quality of life to substantial degree. Apart from a few cross-sectional surveys of large series of psoriatic patients, there have been no formal studies of the natural history and prognosis of established psoriasis. By imposing methodologic control and a numerate approach, epidemiology can offer a major contribution to understand psoriasis.

383 citations


Book ChapterDOI
01 Jan 1986
TL;DR: This term is used to describe disorders in which there is a primary fault in the process of epidermal differentiation and (or) desquamation and includes the ichthyotic disorders.
Abstract: This term is used to describe disorders in which there is a primary fault in the process of epidermal differentiation and (or) desquamation. It includes the ichthyotic disorders and a number of other quite uncommon disorders in which there is scaling and hyperkeratosis.

282 citations