Patterning as a signature of human epidermal stem cell regulation.
Allon M. Klein,Varvara Nikolaidou-Neokosmidou,David P. Doupé,Philip H. Jones,Benjamin D. Simons +4 more
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A model of pattern formation is proposed that explains how clustering could regulate stem cell activity in homeostatic tissue through contact inhibition and stem cell aggregation.Abstract:
Understanding how stem cells are regulated in adult tissues is a major challenge in cell biology. In the basal layer of human epidermis, clusters of almost quiescent stem cells are interspersed with proliferating and differentiating cells. Previous studies have shown that the proliferating cells follow a pattern of balanced stochastic cell fate. This behaviour enables them to maintain homeostasis, while stem cells remain confined to their quiescent clusters. Intriguingly, these clusters reappear spontaneously in culture, suggesting that they may play a functional role in stem cell auto-regulation. We propose a model of pattern formation that explains how clustering could regulate stem cell activity in homeostatic tissue through contact inhibition and stem cell aggregation.read more
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Mammalian skin cell biology: at the interface between laboratory and clinic
TL;DR: Recent insights into the cell biology of skin are discussed, showing skin cells to be remarkably dynamic and revealing unexpected functions for elements of the skin that were previously considered purely structural.
Journal ArticleDOI
Regulation of Human Epidermal Stem Cell Proliferation and Senescence Requires Polycomb- Dependent and -Independent Functions of Cbx4
Nuno Miguel Luis,Lluis Morey,Stefania Mejetta,Gloria Pascual,Peggy Janich,Bernd Kuebler,Luca Cozutto,Guglielmo Roma,Elisabete Nascimento,Michaela Frye,Luciano Di Croce,Salvador Aznar Benitah +11 more
TL;DR: It is shown that Cbx4, a Polycomb Repressive Complex 1 (PRC1)-associated protein, maintains human epidermal stem cells as slow-cycling and undifferentiated, while protecting them from senescence.
Condensed Matter Field Theory
Alexander Altland,Ben D. Simons +1 more
TL;DR: From particle to fields as mentioned in this paper, the renormalization group is used to define the topology of the particle-to-field model, which is then used in the second quantization phase.
Journal ArticleDOI
Lineage Analysis of Epidermal Stem Cells
Maria P. Alcolea,Philip H. Jones +1 more
TL;DR: Recent insights that reveal how a progenitor cell population maintains interfollicular epidermis, whereas stem cells, quiescent under homeostatic conditions, are mobilized in response to wounding are reviewed.
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Mimicking the topography of the epidermal-dermal interface with elastomer substrates.
Priyalakshmi Viswanathan,Murat Guvendiren,Wesley Chua,Stephanie B. Telerman,Kifayathullah Liakath-Ali,Jason A. Burdick,Fiona M. Watt +6 more
TL;DR: A two-step protocol to create patterned substrates that mimic the topographical features of the human epidermal-dermal interface found that cells were patterned according to topography, and that separate cues determined the locations of stem cells, differentiated cells and proliferation cells.
References
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John W. Cahn,John E. Hilliard +1 more
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Michael Cross,P. C. Hohenberg +1 more
TL;DR: A comprehensive review of spatiotemporal pattern formation in systems driven away from equilibrium is presented in this article, with emphasis on comparisons between theory and quantitative experiments, and a classification of patterns in terms of the characteristic wave vector q 0 and frequency ω 0 of the instability.
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A General Method for Numerically Simulating the Stochastic Time Evolution of Coupled Chemical Reactions
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Theory of phase-ordering kinetics
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Defining the epithelial stem cell niche in skin.
Tudorita Tumbar,Géraldine Guasch,Valentina Greco,Cédric Blanpain,William E. Lowry,Michael Rendl,Elaine Fuchs +6 more
TL;DR: It is found that these cells rarely divide within their niche but change properties abruptly when stimulated to exit, and their transcriptional profile is determined, which, when compared to progeny and other SCs, defines the niche.