PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
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453 citations
Cites background from "PD-1/PD-L1 Blockade: Have We Found ..."
...Based on the mechanism mentioned above, PD-1/ PD-L1 inhibitors block the negative regulatory signal pathways and unleash T cell from exhausted status [16]....
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References
10,674 citations
"PD-1/PD-L1 Blockade: Have We Found ..." refers background in this paper
...PD-L1 is the first and most studied biomarker for PD-1 blockade (188, 235)....
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7,474 citations
"PD-1/PD-L1 Blockade: Have We Found ..." refers background in this paper
...(196) Phase 3 CheckMate 057 trial in 582...
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7,053 citations
6,869 citations
"PD-1/PD-L1 Blockade: Have We Found ..." refers background or result in this paper
...Durable response could also be achieved in PD-L1− patients (5, 6)....
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...Cancer Immunol Res (2016) 4(5):419–30....
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...Furthermore, in some studies of squamous NSCLC and renal cell carcinoma, the efficacy of PD-1 blockade (response rate or survival outcome) in PD-L1− patients was similar to or even better than that in PD-L1+ patients (5, 201)....
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...(5) Phase 3 CheckMate 017 trial in 272...
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6,835 citations