Journal ArticleDOI
Pd/C as a reusable catalyst for the coupling reaction of halophenols and arylboronic acids in aqueous media.
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Pd/C was found to catalyze the Suzuki−Miyaura coupling reaction of halophenols in aqueous media, and the palladium catalyst was easily recovered and reused as mentioned in this paper.Abstract:
Pd/C was found to catalyze the Suzuki−Miyaura coupling reaction of halophenols in aqueous media. When halophenols were treated with ArB(OH)2 and a catalytic amount of 10% Pd/C (0.3 mol % Pd) in aqueous K2CO3 solution, the corresponding hydroxybiaryls were obtained in a high yield or quantitatively. The palladium catalyst was easily recovered and reused.read more
Citations
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Carbon-Carbon Coupling Reactions Catalyzed by Heterogeneous Palladium Catalysts
Lunxiang Yin,Jürgen Liebscher +1 more
TL;DR: Pd on Modified Silica 159 4.5.1.
Journal ArticleDOI
On the Nature of the Active Species in Palladium Catalyzed Mizoroki–Heck and Suzuki–Miyaura Couplings – Homogeneous or Heterogeneous Catalysis, A Critical Review
TL;DR: A wide array of forms of palladium has been utilized as precatalysts for Heck and Suzuki coupling reactions over the last 15 years as mentioned in this paper, and there are now many suggestions in the literature that narrow the scope of types of precatalyst that may be considered true catalysts in these coupling reactions.
Journal ArticleDOI
Selected patented cross-coupling reaction technologies.
Journal ArticleDOI
Catalysts for Suzuki−Miyaura Coupling Processes: Scope and Studies of the Effect of Ligand Structure
TL;DR: Structural studies of various 1.Pd complexes are presented along with computational data that help elucidate the efficacy that 1 imparts on Suzuki-Miyaura coupling processes, and a comparison of the reactions is presented that is informative in determining the relative importance of ligand bulk and electron-donating ability in the high activity of catalysts derived from ligands of this type.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Highly Active Palladium Catalysts for Suzuki Coupling Reactions
TL;DR: The most active catalyst system in terms of reaction temperature, turnover number, and steric tolerance has been reported to date as mentioned in this paper, which tolerates a broad range of functional groups and substrate combinations including the use of sterically hindered substrates.
Journal ArticleDOI
Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR
Philip J. Hajduk,G. Sheppard,David G. Nettesheim,Edward T. Olejniczak,Suzanne B. Shuker,R. P. Meadows,D. H. Steinman,G. M. Carrera,P. A. Marcotte,Jean M. Severin,Karl A. Walter,H. Smith,E. Gubbins,Robert L. Simmer,T. F. Holzman,D. W. Morgan,S. K. Davidsen,and J. B. Summers,Stephen W. Fesik +18 more
TL;DR: These studies indicate that the SAR by NMR method can be effectively applied to enzymes to yield potent lead inhibitorsan important part of the drug discovery process.
Journal ArticleDOI
Highly Efficient and Accelerated Suzuki Aryl Couplings Mediated by Phosphine-Free Palladium Sources
Thomas I. Wallow,Bruce M. Novak +1 more
TL;DR: The phosphine-free methodology appears to be generally applicable; cross-couplings of aryl iodides yielding biaryls 6 and 7 proceed without noticeable steric or electronic effects.
Journal ArticleDOI
Aryl couplings with heterogeneous palladium catalysts
TL;DR: The coupling reaction of diverse phenylboronic acids with aryl halogenides and triflates has been performed by the use of simple palladium hydrogenation catalysts as discussed by the authors.
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