PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Hans Boström,Karen Willetts,Karen Willetts,Milos Pekny,Per Levéen,Per Lindahl,Håkan Hedstrand,Marcela Pekna,Mats Hellström,Samuel Gebre-Medhin,Martin Schalling,Mia Nilsson,Siri Kurland,Jan Törnell,John K. Heath,Christer Betsholtz +15 more
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TLDR
The two PDGF null phenotypes reveal analogous morphogenetic functions for myofibroblast-type cells in lung and kidney organogenesis, and show that PDGF-B is required in the ontogeny of kidney mesangial cells.About:
This article is published in Cell.The article was published on 1996-06-14 and is currently open access. It has received 854 citations till now. The article focuses on the topics: Lung emphysema & Myofibroblast.read more
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Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
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Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
TL;DR: The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms/processes that control differentiation of vascular smooth muscle cells (SMC) during normal development and maturation of the vasculature, as well as how these mechanisms/ processeses are altered in vascular injury or disease.
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Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
TL;DR: Structural and functional properties of PDGF and PDGF receptors, the mechanism whereby PDGF exerts its cellular effects, and the role ofPDGF in normal and diseased tissues are discussed.
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Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
TL;DR: Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts, and endothelial cells of the sprouting capillaries in the mutant mice appeared to be unable to attract PDGF-Rbeta-positive pericyte progenitor cells.
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Role of platelet-derived growth factors in physiology and medicine.
TL;DR: Basic aspects of the PDGF ligands and receptors, their developmental and pathological functions, principles of their pharmacological inhibition, and results using PDGF pathway-inhibitory or stimulatory drugs in preclinical and clinical contexts are reviewed.
References
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TL;DR: Some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo, but the serum levels of IgG1 and IgE are strongly reduced.
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HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells.
TL;DR: The realization of this possibility by the selection in vitro of variant ES cells deficient in hypoxanthine guanine phosphoribosyl transferase is reported, leading to their use to produce germline chimaeras resulting in female offspring heterozygous for HPRT-deficiency, and the generation of HPRt-deficient preimplantation embryos from these females.
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Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.
Per Levéen,Milos Pekny,Samuel Gebre-Medhin,Birgitta Swolin,Erik G. Larsson,Christer Betsholtz +5 more
TL;DR: It is shown that mice deficient for PDGF B die perinatally and display several anatomical and histological abnormalities, and it is concluded thatPDGF B has crucial roles in vivo in establishing certain renal and circulatory functions.
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Expression of a Delta homologue in prospective neurons in the chick
TL;DR: It is shown that C-Delta-1 is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided, suggesting that both the Delta/ Notch signalling mechanism and its role in Neurogenesis have been conserved in vertebrates.
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Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.
TL;DR: Results indicate that whereas the beta receptor is essential in certain cell types during embryonic development, its broader role may be masked because of compensation by the alpha-subunit.