Peculiarities of cell death mechanisms in neutrophils.
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Cites background from "Peculiarities of cell death mechani..."
...Neutrophils are short-lived cells that die within a limited time after entering the circulation (Geering and Simon, 2011)....
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...In the absence of infection or inflammation, they die by a spontaneous apoptosis program (Geering and Simon, 2011; Witko-Sarsat et al., 2011), likely within 1 d (although some investigators propose this time to be up to 5 d; Pillay et al., 2010)....
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590 citations
Cites background from "Peculiarities of cell death mechani..."
...Once emigrated, the lifespan of neutrophils can be modified by the local inflammatory environment (Fox et al, 2010; Geering & Simon, 2011; Fig 2B)....
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...Given the central role of neutrophil apoptosis in resolution, strategies aiming at the promotion of neutrophil apoptosis have emerged (Table 1; Geering & Simon, 2011)....
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367 citations
Cites background from "Peculiarities of cell death mechani..."
...In most cases, ROS are believed to be upstream of caspases, and several mechanisms have been proposed; however, only a few ROS targets have been elucidated [29]....
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"Peculiarities of cell death mechani..." refers background in this paper
...Thus, the majority of molecular pathways causing neutrophil apoptosis were shown to be dependent on ROS generation.(38) However, excessive ROS production upon cellular stimulation or the impairment of anti-oxidant defense mechanisms may also result in other neutrophil cell death forms (see also Figure 1), as ROS can damage essential molecules, such as lipids, proteins and DNA....
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"Peculiarities of cell death mechani..." refers background in this paper
...For instance, patients with CGD suffer from a variety of inflammatory conditions.(126) This counter-intuitive finding may be explained by the important role of ROS during neutrophil cell death....
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