PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo.
Kadi-Liis Veiman,Kadri Künnapuu,Tõnis Lehto,Kristina Kiisholts,Kalle Pärn,Ülo Langel,Kaido Kurrikoff +6 more
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TLDR
This work introduces a novel method for in vivo delivery of plasmid DNA (pDNA) and efficient tumor-specific gene induction using intravenous (i.v) administration route and shows that this delivery vector effectively forms nanoparticles, where the condensed CPP and pDNA are shielded by the PEG, in an MMP-reversible manner.About:
This article is published in Journal of Controlled Release.The article was published on 2015-07-10 and is currently open access. It has received 107 citations till now. The article focuses on the topics: Gene delivery & Drug delivery.read more
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Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization.
TL;DR: The typical cancer‐drug‐delivery process of an intravenously administered nanomedicine is analyzed and it is concluded that the delivery involves a five‐step CAPIR cascade and that high efficiency at every step is critical to guarantee high overall therapeutic efficiency.
Journal ArticleDOI
Nonviral cancer gene therapy: Delivery cascade and vector nanoproperty integration.
Zhuxian Zhou,Xiangrui Liu,Dingcheng Zhu,Yue Wang,Zhen Zhang,Xuefei Zhou,Nasha Qiu,Xuesi Chen,Youqing Shen +8 more
TL;DR: This review analyzes the cancer gene‐delivery cascade and the barriers, the needed nanopro properties and the current strategies for overcoming these barriers, and outlines PEGylation, surface‐charge, size, and stability dilemmas in vector nanoproperties to efficiently accomplish the cancer genes delivery cascade.
Journal ArticleDOI
Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery.
Chun-Yang Sun,Song Shen,Cong-Fei Xu,Hongjun Li,Yang Liu,Zhi-Ting Cao,Xianzhu Yang,Jin-Xing Xia,Jun Wang +8 more
TL;DR: Dm-NP achieved both prolonged circulation and effective accumulation in tumor cells and resulted in the safe and enhanced inhibition of non-small cell lung cancer growth.
Journal ArticleDOI
Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity.
TL;DR: A variety of CPP designs will be described, including linear and flexible, positively charged and often amphipathic CPPs, and more rigid versions comprising cyclic, stapled, or dimeric and/or multivalent, self-assembled peptides or peptido-mimetics.
Journal ArticleDOI
Peptides for nucleic acid delivery.
TL;DR: In conclusion, CPP-based drug delivery systems have the capacity to overcome the hurdle of delivery and thus have the potential to facilitate the clinical translation of nucleic acid-based therapeutics.
References
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A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
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Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.
TL;DR: Stealth liposomes can be actively targeted with monoclonal antibodies or ligands and encapsulating active molecules, with high target efficiency and activity by synthetic modification of the terminal PEG molecule.
PatentDOI
Cell Penetrating Peptides
Mattias Hällbrink,Margus Pooga,Madis Tallin Unive Metsis,Priit Kogerman,Andreas Valkna,Anne Meikas,Maria Lindgren,Astrid Gräslund,Göran Eriksson,Claes Göran Östensson,Metka V. Budihna,Matjaz Zorko,Anna Elmquist,Ursel Soomets,Pontus Lundberg,Peter Järver,Külliki Saar,Samir El-Andaloussi,Kalle Kilk,Ülo Langel +19 more
TL;DR: In this paper, a method for predicting or designing, detecting, and/or verifying a novel cell-penetrating peptide (CPP) was proposed and used for treating and preventing a medical condition.
Journal ArticleDOI
Tumor imaging by means of proteolytic activation of cell-penetrating peptides.
TL;DR: In mice xenografted with human tumor cells secreting matrix metalloproteinases 2 and 9, ACPPs bearing a far-red-fluorescent cargo show in vivo contrast ratios of 2-3 and a 3.1-fold increase in standard uptake value for tumors relative to contralateral normal tissue or control peptides with scrambled linkers.
Journal ArticleDOI
A new peptide vector for efficient delivery of oligonucleotides into mammalian cells
TL;DR: This new strategy of oligonucleotide delivery into cultured cells based on a peptide vector offers several advantages compared to other commonly used approaches of delivery including efficiency, stability and absence of cytotoxicity, and is proposed as a powerful tool for potential development in gene and antisense therapy.