Pendulin, a polyoxygenated phenanthrene derivative from the orchid Cymbidium pendulum
TL;DR: In this article, the orchid Cymbidium pendulum was isolated and the structure of the pendulum's phenanthrene derivative, pendulin, was further confirmed by its 13 C NMR spectral data.
About: This article is published in Phytochemistry.The article was published on 1991-01-01. It has received 36 citations till now.
Citations
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TL;DR: The present study furnishes an overview of the hydroxy or/and methoxy-substituted 9,10-dihydro/phenanthrene, methylated, prenylated and other monomeric derivatives, dimeric and trimeric phenanthrenes and their biological activities.
282 citations
TL;DR: Among the identified compounds, five were found to exhibit anti-platelet aggregation activity in vitro and the structure of a previously reported compound dendroflorin obtained from the plant was revised on the basis of spectroscopic analysis.
143 citations
TL;DR: Plant tissue culture could be one of the most suitable alternative tools to minimize the pressure on natural population of medicinal orchids and their sustainable utilization.
Abstract: Orchids are nature's most extravagant group of flowering plants distributed throughout the world from tropics to high alpine. They exhibit incredible range of diversity in size, shape and color of their flowers. Though orchids are grown primarily as ornamentals, many are used as herbal medicines, food, and other have cultural value by different cultures and tribes in different parts of the world. Orchids have been used in many parts of the world in traditional healing system as well as in the treatment of a number of diseases since the ancient time. Though Orchidaceae is regarded as a largest family of plant kingdom, few studies have been done regarding their medicinal properties. Linking of the indigenous knowledge of medicinal orchids to modern research activities provides a new reliable approach, for the discovery of novel drugs much more effectively than with random collection. Many of these orchids face the extreme danger of extinction due to over-exploitation and habitat loss. Plant tissue culture could be one of the most suitable alternative tools to minimize the pressure on natural population of medicinal orchids and their sustainable utilization.
Key words: Medicinal, orchids, propagation, conservation, culture.
142 citations
TL;DR: Compounds 1-3 and denthyrsinin (1,5,7-trimethoxyphenanthrene-2,6-diol; 4) showed significant cytotoxic activities against Hela (13.5, 9.5 and 4.8 microM, respectively) cell lines.
79 citations
Cites background from "Pendulin, a polyoxygenated phenanth..."
...1,5,7-Trimethoxyphenanthrene-2,6-diol (4, CAS Registry No. 118169-17-8) was previously reported by Majumder and Sen (1991) and improperly named as pendulin....
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TL;DR: Antifibrotic activity of compounds 1- 19 was evaluated employing HSC-T6, an immortalized rat hepatic stellate cell line, as an in vitro assay system by assessing cell proliferation.
Abstract: Two new phenanthrenes (1 and 6) and four new dihydrophenanthrenes (2–5) were isolated from a methanolic extract of Dendrobium nobile stems, along with 13 known phenanthrenes and dihydrophenanthrenes (7–19). By spectroscopic analysis, the structures of compounds 1–6 were determined as 2,8-dihydroxy-3,4,7-trimethoxyphenanthrene (1), 3-hydroxy-2,4,7-trimethoxy-9,10-dihydrophenanthrene (2), 2,8-dihydroxy-3,4,7-trimethoxy-9,10-dihydrophenanthrene (3), 2-hydroxy-4,7-dimethoxy-9,10-dihydrophenanthrene (4), 2,2′-dihydroxy-3,3′,4,4′,7,7′-hexamethoxy-9,9′,10,10′-tetrahydro-1,1′-biphenanthrene (5), and 2,3,5-trihydroxy-4,9-dimethoxyphenanthrene (6), respectively. Antifibrotic activity of compounds 1–19 was evaluated employing HSC-T6, an immortalized rat hepatic stellate cell line, as an in vitro assay system by assessing cell proliferation.
53 citations
References
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TL;DR: An amorphous phenanthrene, named nudol has been isolated from Eulophia nuda, Eria carinata and E. stricta and was identified as 2,7-dihydroxy-3,4-dimethoxyphenanthrene.
74 citations
TL;DR: Lusianthrin and lusian-thridin, two new stilbenoids, were isolated from the orchid Lusia indivisa.
66 citations
TL;DR: From the tubers of Eulophia nuda six phenanthrene derivatives have been isolated: 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol, 9, 10dihdroid-2.5dimethoxide-4methoxymethylphenanthrene -2,7diol; 1,5dimethylphenethylamine-1.7-Diol; and 4,4′, 8,8,8-8′-tetrameth
63 citations
TL;DR: Two new polyoxygenated phenanthrene derivatives, confusarin and confusaridin, are isolated from the orchid Eria confusa and are shown to be 2,7-dihydroxy-3,4,8-trimethoxyphenanthrene and 2,6- dihydrox-2,6,7, 8-tetramethoxyrene, respectively.
46 citations
TL;DR: Bulbophyllanthrin, a novel phenanthrene derivative from the orchid B. leopardium, was shown to have the structure 1a mainly on the basis of spectral evidence including 13 C and 2D NMR spectra as discussed by the authors.
43 citations