Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Journal ArticleDOI
Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.
TL;DR: This review summarizes the potential of triterpenes belonging to the lupane, oleanane or ursane group, to treat cancer by different modes of action and utilisation of different plants as their sources is of interest.
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Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease
Karen T. Liby,Michael B. Sporn +1 more
TL;DR: In these interactions, the addition of SOs to reactive cysteine residues in specific molecular targets triggers biological activity, Ultimately, SOs are multifunctional drugs that regulate the activity of entire networks.
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Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities
TL;DR: The current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented.
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TL;DR: A number of small molecules that have the potential to prevent eNOS uncoupling and, at the same time, enhance eN OS expression are identified and may have therapeutic potential.
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Natural inhibitors of pancreatic lipase as new players in obesity treatment.
TL;DR: Hundreds of extracts are currently being isolated from plants, fungi, algae, or bacteria with an inhibitory effect on pancreatic lipase activity, which could be applied in the management of the obesity epidemic.
References
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Dr. Duke's Phytochemical and Ethnobotanical Databases
TL;DR: (+)-CATECHIN Plant: ACE-Inhibitor 0.24 mg/ml rbt (weak activity) IC50=0.155 mM/l; Antiaggregant IC68=200 ug/ml; Anticoagulant; Anticomplementary 1/2 aspirin; AntiHIV EC50=4 ug/.
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Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species.
TL;DR: The tested compounds, which possess immunostimulating activities, may contribute to the traditional claims of Plantago-based natural products used in treating cancers and infectious diseases.
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Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE)
Kumiko Horiuchi,Kumiko Horiuchi,Sumiko Shiota,Tsutomu Hatano,Takashi Yoshida,Teruo Kuroda,Tomofusa Tsuchiya +6 more
TL;DR: An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE), and the effective compound was identified as oleanolic acid, a triterpenoid.
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Formulation Development and Bioavailability Evaluation of a Self-Nanoemulsified Drug Delivery System of Oleanolic Acid
Jia Xi,Qi Chang,Chak K. Chan,Zhao Yu Meng,Geng Nan Wang,Jia Bei Sun,Yitao Wang,Henry H.Y. Tong,Ying Zheng +8 more
TL;DR: The potential use of SNEDDS to improve dissolution and oral bioavailability for poorly water-soluble triterpenoids such as OA is suggested.