Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.
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Cites background from "Pentacyclic triterpenes of the lupa..."
...…by natural and semi-synthetic triterpenoids, alongside the triterpenoid and steroidal saponins and steroidal glycoalkaloids (Kannaiyan et al., 2011; Laszczyk, 2009; Lee et al., 2011; Liby & Sporn, 2012; Pollier & Goossens, 2012; Raju & Mehta, 2009; Shanmugam et al., 2013; Wu et al., 2007; Yadav et…...
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288 citations
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Cites background from "Pentacyclic triterpenes of the lupa..."
...They predominantly are found in various plants including seaweeds as well as in wax-like coatings of various fruits and medicinal herbs, including apples, cranberries, figs, olives, mistletoe, lavender, oregano, rosemary and thyme (21, 26, 28-30)....
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...An increasing number of triterpenoids have been reported to exhibit cytotoxicity against a variety of cancer cells without manifesting any toxicity in normal cells (24, 26, 27)....
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...The use of triterpenoids and related compounds for either chemoprevention or therapy of mammary carcinoma has not been extensively discussed previously although several excellent articles provide an overview of the antitumor potential of these agents against various cancers (24-27)....
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...They also demonstrate antitumor efficacy in preclinical animal models of cancer (26, 27)....
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260 citations
Cites background from "Pentacyclic triterpenes of the lupa..."
...Therefore different steps of the apoptotic process should be targeted to bypass such blocks [1]....
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References
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