Journal ArticleDOI
People with intellectual disability: What do we know about adulthood and life expectancy?
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TLDR
With the exception of people with severe and multiple disabilities or Down syndrome, the life expectancy of this group now closely approximates with that of the general population.Abstract:
Increases in the life expectancy of people with Intellectual Disability have followed similar trends to those found in the general population. With the exception of people with severe and multiple disabilities or Down syndrome, the life expectancy of this group now closely approximates with that of the general population. Middle and old age, which until 30 years ago were not recognized in this population, are now important parts of the life course of these individuals. Older adults with Intellectual Disabilities form a small, but significant and growing proportion of older people in the community. How these persons grow older and how symptoms and complications of the underlying cause of the Intellectual Disability will influence their life expectancy is of the utmost importance.read more
Citations
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Cause of death and potentially avoidable deaths in Australian adults with intellectual disability using retrospective linked data
TL;DR: Adults with ID experience premature mortality and over-representation of potentially avoidable deaths and a national system of reporting of deaths in adults with ID is required to address premature deaths and health inequalities.
Journal ArticleDOI
Cornelia de Lange syndrome.
TL;DR: A brief review of the clinical features of CdLS, the known underlying genetic defects, prenatal and postnatal diagnosis possibilities, and genetic counseling are summarized.
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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome
Arnaud Duchon,Yann Herault +1 more
TL;DR: Recent advances in the development of kinase inhibitors are expected, in the near future, to remove DS from the list of incurable diseases, providing certain conditions such as drug dosage and correct timing for the optimum long-term treatment.
Journal ArticleDOI
Mortality among a Cohort of Persons with an Intellectual Disability in New South Wales, Australia
TL;DR: It is indicated that females with an intellectual disability have a higher relative mortality compared to female same-aged general population peers, and also males with a intellectual disability, a finding replicated in other similar cohort studies.
Journal ArticleDOI
Contextual Factors Predict Patterns of Change in Functioning over 10 Years Among Adolescents and Adults with Autism Spectrum Disorders
TL;DR: Above and beyond demographic and individual characteristics, aspects of both the educational context and the family context were found to predict the likelihood of following a positive pattern of change.
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Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome
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TL;DR: Hemizygosity at the elastin locus is identified using genetic analyses in four familial and five sporadic cases of Williams syndrome, indicating that deletions involving oneElastin allele cause WS and implicate elast in hemizygosa in the pathogenesis of the disease.