Journal ArticleDOI
Peptide-based soft materials as potential drug delivery vehicles.
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TLDR
Morphological properties of peptide-containing self-assembled tubular and vesicular soft structures and their ability to encapsulate drugs, biologicals and bioactive small molecules, with the promise of targeted delivery, are discussed.Abstract:
Emerging concepts in the construction of nanostructures hold immense potential in the areas of drug delivery and targeting. Such nanoscopic assemblies/structures, similar to natural proteins and self-associating systems, may lead to the formation of programmable soft structures with expanded drug delivery options and the capability to circumvent first-pass metabolism. This article aims to illustrate key recent developments and innovative bioinspired design paradigms pertaining to peptide-containing self-assembled tubular and vesicular soft structures. Soft structures are composed of components that self-assemble to reveal diverse morphologies stabilized by weak, noncovalent interactions. Morphological properties of such structures and their ability to encapsulate drugs, biologicals and bioactive small molecules, with the promise of targeted delivery, are discussed.read more
Citations
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Journal ArticleDOI
Optimized Hydrophobic Interactions and Hydrogen Bonding at the Target-Ligand Interface Leads the Pathways of Drug-Designing
Rohan Patil,Suranjana Das,Ashley Stanley,Lumbani Yadav,Akulapalli Sudhakar,Akulapalli Sudhakar,Akulapalli Sudhakar,Ashok K. Varma +7 more
TL;DR: It is demonstrated that hydrogen bonding and optimized hydrophobic interactions both stabilize the ligands at the target site, and help alter binding affinity and drug efficacy.
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Advanced Agrochemical Formulations through Encapsulation Strategies
Beate Hack,Holger Egger,Jens Uhlemann,Michel Henriet,Wolfgang Wirth,Arnoldus W.P. Vermeer,Daniel Gordon Duff +6 more
TL;DR: The development and accomplishments of encapsulation strategies in the agrochemical field are reviewed in this paper and reasons for the encapsulation of agrochemicals are given and put into context with the opportunities and risks for this kind of formulation.
Journal ArticleDOI
Vesicles from Peptidic Side-Chain Polymers Synthesized by Atom Transfer Radical Polymerization
TL;DR: Circular dichroism demonstrates that secondary structuring is observed in the hydrophobic region of the vesicle walls for the valine side-chain containing polymers.
Journal ArticleDOI
A Challenge for Peptide Coarse Graining: Transferability of Fragment-Based Models
Journal ArticleDOI
Sunlight mediated disruption of peptide-based soft structures decorated with gold nanoparticles.
Apurba Kr. Barman,Sandeep Verma +1 more
TL;DR: In this paper, morphological studies of a novel C3-symmetric thiolated, tren-based ditryptophan conjugate have been conducted, where exposed thiol groups on the soft structures interacted with gold nanoparticles and mediated the release of encapsulated fluorescent dye, when exposed to natural sunlight.