Performance of cervical cancer screening and triage strategies among women living with HIV in China
Rufei Duan,Xuelian Zhao,Hongyun Zhang,Xiaoqian Xu,Liuye Huang,Aihui Wu,Le Li,You-Lin Qiao,Fang-Hui Zhao +8 more
Reads0
Chats0
TLDR
Li et al. as discussed by the authors evaluated the clinical performance of liquid-based cytology (LBC), HPV tests and visual inspections with acetic acid or Lugol's iodine (VIA/VILI) as primary screening and triage strategies among Chinese women living with HIV (WLHIV).Abstract:
OBJECTIVES To evaluate the clinical performance of liquid-based cytology (LBC), HPV tests and visual inspections with acetic acid or Lugol's iodine (VIA/VILI) as primary screening and triage strategies among Chinese women living with HIV (WLHIV). METHODS WLHIV aged 18 years and older were recruited from HIV/AIDS treatment clinic in Yunnan, China from 2019 to 2020. Women were screened with self- and physician-sampling for HPV tests, LBC, and VIA/VILI. Women positive for any HPV or with cytological abnormalities were recalled for colposcopy examination and biopsy when necessary. Clinical performance of primary and triage strategies for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was evaluated. RESULTS For primary screening, sensitivity of physician-HPV tests was 100%, 89.5%, and 100% for hybrid capture 2 (HC2), cobas, and Sansure HPV, and specificity was 80.4%, 85.1%, and 72.0%, respectively. Self-HPV test achieved considerable performance with physician-HPV. Sensitivity and specificity were 61.1% and 96.3% for LBC (atypical squamous cells of undetermined significance or worse [ASCUS+]), 40.0% and 77.3% for VIA/VILI. For triaging HPV-positive women, LBC (ASCUS+), HPV-16/18 genotyping, and VIA/VILI-elevated specificity with sensitivity declined 30%-50% compared with HPV screening alone. Restricted HPV genotyping triage (HPV-16/18/31/33/45/52/58) demonstrated the optimal accuracy (89.5% sensitivity, 81.9% specificity), and was similar to HPV-16/18 with reflex LBC (ASCUS+). Combination antiretroviral therapies (cARTs) <2 years were associated with decreased specificity of HC2 (aOR: 1.87, 95% CI: 1.22-3.91) and Sansure HPV (2.48, 1.43-4.29). CONCLUSIONS Self-HPV with restricted genotyping triage is highly recommended for cervical cancer screening for WLHIV in China. Feasible triage to increase HPV specificity among women with short duration of cART is needed.read more
Citations
More filters
Journal ArticleDOI
Cervical cancer prevention and control in women living with human immunodeficiency virus.
TL;DR: A critical appraisal of the evidence to date on the impact of HIV disease on cervical cancer risk, describe key methodologic issues, and frame the key outstanding research questions, especially as they apply to ongoing global efforts for prevention and control of cervical cancer as mentioned in this paper.
Journal ArticleDOI
Diagnostic accuracy of cervical cancer screening strategies for high-grade cervical intraepithelial neoplasia (CIN2+/CIN3+) among women living with HIV: A systematic review and meta-analysis
Helen Kelly,I Jaafar,Michael Chung,Pam Michelow,Sharon K. Greene,Howard D. Strickler,Xianhong Xie,Mark Schiffman,Nathalie Broutet,Philippe Mayaud,Shona Dalal,Marc Arbyn,Silvia de Sanjosé +12 more
TL;DR: In this paper , the diagnostic accuracy of cervical cancer screening and triage strategies in women living with HIV (WLHIV) was systematically reviewed for the detection of histologically-confirmed high-grade cervical intraepithelial neoplasia (CIN2+/CIN3+) among WL HIV patients.
Journal ArticleDOI
High-risk human papillomavirus genotype distribution among women living with HIV; implication for cervical cancer prevention in a resource limited setting
Patrick Kafui Akakpo,Sebastian Ken-Amoah,Nancy Innocentia Ebu Enyan,E. Agyare,I.K. Baidoo,Leonard Derkyi-Kwarteng,Matthew Asare,G. A. Adjei,Stephen Ayisi Addo,Dorcas Obiri-Yeboah +9 more
TL;DR: In this article , a cross-sectional study was conducted at the Cape Coast Teaching Hospital in Ghana to determine the distribution of high-risk HPV genotype and related factors among women living with HIV and its implication for the prevention of cervical cancer prevention efforts.
References
More filters
Journal ArticleDOI
1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults
Kenneth G. Castro,John W. Ward,Laurence Slutsker,James W. Buehler,Harold W. Jaffe,Ruth L. Berkelman,James Curran +6 more
TL;DR: The classification system for HIV infection is revised to emphasize the clinical importance of the CD4+ T-lymphocyte count in the categorization of HIV-related clinical conditions and the AIDS surveillance case definition is expanded.
Journal ArticleDOI
Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer.
Marc Arbyn,Guglielmo Ronco,Ahti Anttila,Chris J.L.M. Meijer,Mario Poljak,Gina Ogilvie,George Koliopoulos,Pontus Naucler,Rengaswamy Sankaranarayanan,Julian Peto +9 more
TL;DR: There exists a substantial evidence base to support that HPV testing is advantageous both in triage of women with equivocal abnormal cytology, in surveillance after treatment of CIN lesions and in primary screening of women aged 30 years or older, however, the possible advantages offered by HPV-based screening require a well organised program with good compliance with screening and triage policies.
Journal ArticleDOI
2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors.
Rebecca B. Perkins,Richard S. Guido,Philip E. Castle,David Chelmow,Mark H. Einstein,Francisco A.R. Garcia,Warner K. Huh,Jane J. Kim,Anna-Barbara Moscicki,Ritu Nayar,Mona Saraiya,George F. Sawaya,Nicolas Wentzensen,Mark Schiffman +13 more
TL;DR: The 2019 ASCCP Risk-Based Management Consensus Guidelines Committee concluded that the current consensus on risk-based management guidelines is inadequate and called for further work on this issue.
Journal ArticleDOI
Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses
TL;DR: To evaluate the diagnostic accuracy of high-risk human papillomavirus (hrHPV) assays on self samples and the efficacy of self sampling strategies to reach underscreened women, pilots should be set up before regional or national roll out of self sample strategies.
Journal ArticleDOI
Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study
Silvia Franceschi,Mauro Lise,Gary M. Clifford,Martin Rickenbach,Fabio Levi,Manuela Maspoli,Christine Bouchardy,Silvia Dehler,Gernot Jundt,Silvia Ess,Andrea Bordoni,Isabelle Konzelmann,Harald Frick,L. Dal Maso,Luigia Elzi,Hansjakob Furrer,Alexandra Calmy,Matthias Cavassini,Bruno Ledergerber,Olivia Keiser +19 more
TL;DR: Increases in the incidence of selected NADCs after the introduction of HAART were largely accounted for by the ageing of PWHA, which was similar in all periods, and approximately double that in the general population.
Related Papers (5)
Diagnostic accuracy of high-risk HPV DNA genotyping for primary cervical cancer screening and triage of HPV-positive women, compared to cytology: preliminary results of the PIPAVIR study
Kimon Chatzistamatiou,Theodoros Moysiadis,Eleftherios Angelis,Andreas M. Kaufmann,Alkmini Skenderi,Pidder Jansen-Duerr,Irini Lekka,Vasilis Kilintzis,Stamatia Angelidou,Evangelia Katsiki,Ingke Hagemann,Athena Tsertanidou,Isabel Koch,Oliver Boecher,Erwin Soutschek,Nikolaos Maglaveras,Theodoros Agorastos +16 more