Journal ArticleDOI
Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat.
L. Earl Gray,Joseph S. Ostby,Johnathan Furr,Matthew Price,D.N. Rao Veeramachaneni,Louise G. Parks +5 more
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TLDR
It is hypothesized that the phthalate esters that altered testis function in the pubertal male rat would also alter testisfunction in the fetal male and produce malformations of androgen-dependent tissues and, in summary, DEHP, BBP, and DINP all altered sexual differentiation, whereas DOTP, DEP, or DMP were ineffective at this dose.About:
This article is published in Toxicological Sciences.The article was published on 2000-12-01. It has received 1020 citations till now. The article focuses on the topics: Phthalate & Diisononyl phthalate.read more
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Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Evanthia Diamanti-Kandarakis,Jean-Pierre Bourguignon,Linda C. Giudice,Russ Hauser,Gail S. Prins,Ana M. Soto,R. Thomas Zoeller,Andrea C. Gore +7 more
TL;DR: The evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology is presented.
Journal ArticleDOI
Decrease in anogenital distance among male infants with prenatal phthalate exposure
Shanna H. Swan,Katharina M. Main,Fan Liu,Sara Stewart,Robin L. Kruse,Antonia M. Calafat,Catherine S. Mao,J. Bruce Redmon,Christine L. Ternand,S.J. Sullivan,J.Lynn Teague +10 more
TL;DR: The hypothesis that prenatal phthalate exposure at environmental levels can adversely affect male reproductive development in humans is supported.
Journal ArticleDOI
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
Andrea C. Gore,Vesna A. Chappell,Suzanne E. Fenton,Jodi A. Flaws,Angel Nadal,Gail S. Prins,Jorma Toppari,R. T. Zoeller +7 more
TL;DR: A much more complete understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability, can be much better translated to human health.
Journal ArticleDOI
State of the Science of Endocrine Disrupting Chemicals - 2012
TL;DR: The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of UNEP or WHO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.
Journal ArticleDOI
What are the sources of exposure to eight frequently used phthalic acid esters in Europeans
TL;DR: The scenario‐based approach chosen in the present study provides a link between the knowledge on emission sources of phthalates and the concentrations ofphthalate metabolites found in human urine, which demonstrates that exposure of infant and adult consumers is caused by different sources in many cases.
References
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Journal ArticleDOI
Evidence for decreasing quality of semen during past 50 years.
TL;DR: There has been a genuine decline in semen quality over the past 50 years, and as male fertility is to some extent correlated with sperm count the results may reflect an overall reduction in male fertility.
Journal ArticleDOI
Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract
TL;DR: It is argued that the increasing incidence of reproductive abnormalities in the human male may be related to increased oestrogen exposure in utero, and mechanisms by which this exposure could occur are identified.
Book
Chemically-induced alterations in sexual and functional development : the wildlife/human connection
Theo Colborn,Coralie Clement +1 more
TL;DR: The role of mesenchyme in the development of the urogenital tract was discussed by Howard A. Bern and M.M. van Saal as discussed by the authors, who found evidence of contaminant-induced alterations in sexual development in free-living wildlife.
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The Plasticizer Diethylhexyl Phthalate Induces Malformations by Decreasing Fetal Testosterone Synthesis during Sexual Differentiation in the Male Rat
Louise G. Parks,Joe Ostby,Christy R. Lambright,Barbara D. Abbott,Gary R. Klinefelter,Norman J. Barlow,L. Earl Gray +6 more
TL;DR: Data indicate that DEHP disrupts male rat sexual differentiation by reducing T to female levels in the fetal male rat during a critical stage of reproductive tract differentiation.
Journal ArticleDOI
Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat.
Cynthia J. Wolf,Christy S. Lambright,Peter C. Mann,Matthew Price,Ralph L. Cooper,Joseph S. Ostby,L. Earl Gray +6 more
TL;DR: The analysis indicates that the chemicals discussed here can be clustered into three or four separate groups, based on the resulting profiles of reproductive effects, and suggests that L may display several mechanisms of endocrine toxicity, one of which involves AR binding.