Journal ArticleDOI
Periodontitis: facts, fallacies and the future
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TLDR
Research during the past 25 years has significantly changed the concepts of periodontitis pathobiology and has produced more-effective and less-costly therapeutic options.Abstract:
This volume of Periodontology 2000 represents the 25th anniversary of the Journal, and uses the occasion to assess important advancements in periodontology over the past quarter-century as well as the hurdles that remain. Periodontitis is defined by pathologic loss of the periodontal ligament and alveolar bone. The disease involves complex dynamic interactions among active herpesviruses, specific bacterial pathogens and destructive immune responses. Periodontal diagnostics is currently based on clinical rather than etiologic criteria, and provides limited therapeutic guidance. Periodontal causative treatment consists of scaling, antiseptic rinses and occasionally systemic antibiotics, and surgical intervention has been de-emphasized, except perhaps for the most advanced types of periodontitis. Plastic surgical therapy includes soft-tissue grafting to cover exposed root surfaces and bone grafting to provide support for implants. Dental implants are used to replace severely diseased or missing teeth, but implant overuse is of concern. The utility of laser treatment for periodontitis remains unresolved. Host modulation and risk-factor modification therapies may benefit select patient groups. Patient self-care is a critical part of periodontal health care, and twice-weekly oral rinsing with 0.10-0.25% sodium hypochlorite constitutes a valuable adjunct to conventional anti-plaque and anti-gingivitis treatments. A link between periodontal herpesviruses and systemic diseases is a strong biological plausibility. In summary, research during the past 25 years has significantly changed our concepts of periodontitis pathobiology and has produced more-effective and less-costly therapeutic options.read more
Citations
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Polydopamine Nanoparticles as Efficient Scavengers for Reactive Oxygen Species in Periodontal Disease
TL;DR: A high-performance platform is developed by using biodegradable polydopamine nanoparticles (PDA NPs) as smart ROS scavengers in oxidative stress-induced periodontal disease to provide valuable insight into the development of safe and efficient antioxidant defense platforms for further biomedical uses.
Journal ArticleDOI
Association between periodontitis and severity of COVID-19 infection: A case-control study.
Nadya Marouf,Wenji Cai,Khalid N. Said,Hanin I. Daas,Hanan Diab,Venkateswara R. Chinta,Ali Ait Hssain,Belinda Nicolau,Mariano Sanz,Faleh Tamimi +9 more
TL;DR: In this paper, the authors investigated the association of periodontitis with COVID-19 complications including death, ICU admission, need for assisted ventilation, and increased blood levels of biomarkers linked to worse disease outcomes.
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Current concepts in the management of periodontitis
TL;DR: The aim of this review is to provide current concepts of diagnosis, prevention and treatment of periodontitis, and both clinical and biological rationales will be discussed.
Journal ArticleDOI
Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review.
TL;DR: The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.
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A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization.
TL;DR: In this article, a simple multifunctional nanocomposite was fabricated by coating red light-excited photosensitizer chlorin e6 (Ce6) onto nanoceria, achieving simultaneous sterilization and inflammation elimination via a dual directional regulation effect.
References
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Journal ArticleDOI
Periodontitis: from microbial immune subversion to systemic inflammation
TL;DR: The mechanisms of microbial immune subversion that tip the balance from homeostasis to disease in oral or extra-oral sites are discussed.
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Global Burden of Severe Periodontitis in 1990-2010 A Systematic Review and Meta-regression
Nicholas J Kassebaum,Eduardo Bernabé,Manu Dahiya,Bishal Bhandari,Christopher J L Murray,Wagner Marcenes +5 more
TL;DR: Policy makers need to be aware of a predictable increasing burden of SP due to the growing world population associated with an increasing life expectancy and a significant decrease in the prevalence of total tooth loss throughout the world from 1990 to 2010.
Journal ArticleDOI
Global burden of oral conditions in 1990-2010: a systematic analysis
Wagner Marcenes,Nicholas J Kassebaum,Eduardo Bernabé,Abraham D. Flaxman,Mohsen Naghavi,Alan D. Lopez,Alan D. Lopez,Christopher J L Murray +7 more
TL;DR: The global burden of untreated caries, severe periodontitis, and severe tooth loss in 2010 is reported on and the challenge in responding to the diversity of urgent oral health needs worldwide is highlighted, particularly in developing communities.
Journal ArticleDOI
Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012.
Paul I. Eke,Bruce A. Dye,Liang Wei,Gary D. Slade,Gina Thornton-Evans,Wenche S. Borgnakke,George W. Taylor,Roy C. Page,James D. Beck,Robert J. Genco +9 more
TL;DR: A high prevalence of periodontitis in US adults aged ≥30 years is confirmed, with almost fifty-percent affected, and the prevalence was greater in non-Hispanic Asians than non- Hispanic whites, although lower than other minorities.
Trends in oral health status: United States, 1988-1994 and 1999-2004.
Bruce A. Dye,Sylvia Tan,Vincent C. Smith,Brenda G Lewis,Laurie K. Barker,Gina Thornton-Evans,Paul I. Eke,Eugenio D. Beltrán-Aguilar,Alice M Horowitz,Chien-Hsun Li +9 more
TL;DR: For most Americans, oral health status has improved between 1988-1994 and 1999-2004, and improvements were seen in dental caries prevalence, tooth retention, and periodontal health.
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Panos N. Papapanou,Mariano Sanz,Nurcan Buduneli,Thomas Dietrich,Magda Feres,Daniel H. Fine,Thomas Frank Flemmig,Raul I. Garcia,William V. Giannobile,Filippo Graziani,Henry Greenwell,David Herrera,Richard T. Kao,Moritz Kebschull,Moritz Kebschull,Denis F. Kinane,Keith L. Kirkwood,Thomas Kocher,Kenneth S. Kornman,Purnima S. Kumar,Bruno G. Loos,Eli E. Machtei,Huanxin Meng,Andrea Mombelli,Ian Needleman,Steven Offenbacher,Gregory J. Seymour,Ricardo Teles,Maurizio S. Tonetti +28 more