Peripheral microangiopathy in precapillary pulmonary hypertension: a nailfold video capillaroscopy prospective study.
Alexandra Arvanitaki,George Giannakoulas,Eva Triantafyllidou,Christos Feloukidis,Afroditi K. Boutou,Alexandros Garyfallos,Haralambos Karvounis,Theodoros Dimitroulas +7 more
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In this paper, the presence of nailfold video-capillaroscopic (NVC) structural changes in patients with precapillary pulmonary hypertension and to identify possible associations of NVC measurements with markers of disease severity was investigated.Abstract:
Although pulmonary vascular bed has been the main subject of research for many years in pulmonary hypertension (PH), interest has recently started to divert towards the possibility of a co-existing peripheral microangiopathy. The aim of the current study was to investigate the presence of nailfold video-capillaroscopic (NVC) structural changes in patients with precapillary PH and to identify possible associations of NVC measurements with markers of disease severity. Α prospective case–control study was performed in 28 consecutive patients with precapillary PH [14 with idiopathic pulmonary arterial hypertension (IPAH) and 14 with chronic thromboembolic pulmonary hypertension (CTEPH)] and 30 healthy controls. NVC quantitative and qualitative parameters were evaluated using Optilia Digital Capillaroscope. To ensure inter-observer repeatability capillaroscopic images were reviewed by two independent investigators. For multiple comparisons among continuous variables, one-way ANOVA or the Kruskal–Wallis test were used. Differences between the groups were tested with post-hoc analysis with adjustment for multiple comparisons (Bonferroni test). Both IPAH (71.4% were women, mean age 53.1 ± 13.4 years) and CTEPH (64.3% women, mean age 60.9 ± 14.4 years) groups presented reduced capillary density compared to healthy controls (8.4 ± 1.2 loops/mm and 8.0 ± 1.2 loops/mm vs. 9.7 ± 0.81 loops/mm, p < 0.001) and increased loop width (15.7 ± 3.9 μm and 15.8 ± 1.9 μm vs. 11.5 ± 2.3 μm, p < 0.001). More than half of patients with IPAH presented microhaemorrhages on capillary nailfold, while increased shape abnormalities in capillary morphology and more capillary thrombi per linear mm were detected in patients with CTEPH compared to patients with IPAH and healthy controls. All PH patients presented a non-specific NVC pattern compared to controls (p < 0.001). The findings of the study reveal a degree of significant peripheral microvascular alterations in patients with IPAH and CTEPH, suggesting a generalized impairment of peripheral microvasculature in pulmonary vascular disease.read more
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Nailfold Capillaroscopy in Systemic Sclerosis Patients with and without Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.
Ioanna Minopoulou,Marieta Theodorakopoulou,Afroditi K. Boutou,Alexandra Arvanitaki,Alexandra Arvanitaki,Georgia Pitsiou,Michael Doumas,Pantelis Sarafidis,Theodoros Dimitroulas +8 more
TL;DR: In this article, the extent of peripheral microvasculopathy assessed through nailfold capillaroscopy might correlate with the presence of pulmonary arterial hypertension (PAH) in SSc patients.
Journal ArticleDOI
New Noninvasive Methods to Evaluate Microvascular Structure and Function
TL;DR: The structural and functional alterations of microvessels are detected because of physiological aging and in several cardiometabolic diseases, including hypertension, diabetes, and obesity as mentioned in this paper , often accompanied by endothelial dysfunction.
Journal ArticleDOI
Peripheral microangiopathy in Eisenmenger syndrome: A nailfold video capillaroscopy study
Alexandra Arvanitaki,George Giannakoulas,Eva Triantafyllidou,Christos Feloukidis,Afroditi K. Boutou,Alexandros Garyfallos,Haralambos Karvounis,Gerhard-Paul Diller,Michael A. Gatzoulis,Theodoros Dimitroulas +9 more
TL;DR: In this paper, the authors demonstrate the presence of systemic microvascular abnormalities in patients with Eisenmenger syndrome using nailfold video-capillaroscopy (NVC) and identify potential correlations of nailfold capillaroscopic characteristics with non-invasive markers of systemic organ function.
Journal ArticleDOI
Peripheral microcirculatory abnormalities are associated with cardiovascular risk in systemic sclerosis: a nailfold video capillaroscopy study
Eleni Pagkopoulou,Stergios Soulaidopoulos,Eva Triantafyllidou,Alexandra Arvanitaki,Niki Katsiki,Chalarampos Loutradis,Asterios Karagiannis,Michael Doumas,Alexandros Garyfallos,George D. Kitas,Theodoros Dimitroulas +10 more
TL;DR: In this paper, the association between micro- and macro-vascular function by utilizing a broad spectrum of assessments of vascular performance was assessed using a nailfold video capillaroscopy (NVC).
Journal ArticleDOI
Capillaroscopic analysis of the microvascular status in mixed versus undifferentiated connective tissue disease.
Carmen Pizzorni,G. Ferrari,C. Schenone,Elvis Hysa,Luca Carmisciano,E. Gotelli,Greta Pacini,Alberto Sulli,Sabrina Paolino,Vanessa Smith,Maurizio Cutolo +10 more
TL;DR: In this article , the authors compared the NVC microvascular status in Mixed Connective Tissue Disease (MCTD) versus the Undifferentiated connective tissue diseases (UCTD), and to search correlations between NVC findings and specific autoantibodies in UCTD patients.
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