Figure 1 | The peroxiredoxin active site is highly conserved in all domains of life. a, Multiple sequence alignment showing peroxiredoxin amino acid sequences. The highly conserved active site is underlined. Representatives shown from Eukaryota (At,A. thaliana; Ce,Caenorhabditis elegans; Dm,D. melanogaster;Hs,Homo sapiens;Mm,M. musculus; Nc, N. crassa; Ot, O. tauri; Sc, S. cerevisiae), Bacteria (Se, S. elongatus sp. PCC7942) and Archaea (Has,H. salinarum sp. NRC-1). b, Critical residues in the active site of 2-Cys peroxiredoxins (in bold) are conserved in all organisms. Structures were derived fromhuman PRX-V (ProteinData Bank (PDB) accession 1HD2)47 and human PRDX2 (PDB accession 1QMV)48, and modified with PyMOL to show the predicted structure for archaeal peroxiredoxin (HyrA, GenBank accession NP_280562.1).
...read more