Q1. What are the contributions mentioned in the paper "Pesticides that inhibit the ubiquitin-proteasome system: effect measure modification by genetic variation in skp1 in parkinson׳s disease" ?
Their goal in this study was to screen pesticides for proteasome inhibition and investigate ( i ) whether ambient exposures to pesticides that inhibit the UPS increase PD risk and ( ii ) whether genetic variation in candidate genes of the UPS pathway modify those increased risks. The authors recruited idiopathic PD cases ( n1⁄4360 ) and population-based controls ( n1⁄4816 ) from three counties in California with considerable commercial agriculture. Their results provide evidence that UPS-inhibiting pesticides play a role in the etiology of PD and suggest that genetic variation in candidate genes involved in the UPS pathway might exacerbate the toxic effects of pesticide exposures.