Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
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Journal Article
Wafers: an innovative advancement of oro-dispersible films
Paramita Dey,Arnabi Ghosh +1 more
TL;DR: The formulation of oral disintegrating films has led to the development of wafers which has modified itself in the recent past years as mentioned in this paper, which has become popular between geriatric and paediatric population because of its ease of administration and bioavailability.
Journal ArticleDOI
Preliminary investigation of peroxide levels of Plasdone™ copovidones on the purity of atorvastatin calcium amorphous solid dispersions: Impact of plasticizers on hot melt extrusion processability
Sandeep Sarabu,Arun Butreddy,Suresh Bandari,Amol Batra,Kamaru Lawal,N. N. Chen,Michael Kogan,Vivian Bi,Thomas Durig,Michael A. Repka +9 more
TL;DR: In this article , the authors evaluated the effect of Plasdone™ 630 copovidone grades on the degradation and purity levels of Atorvastatin calcium trihydrate (ACT) amorphous solid dispersions (ASDs) prepared via hot melt extrusion (HME).
Book ChapterDOI
HME for Solid Dispersions: Scale-Up and Late-Stage Development
Chad D. Brown,James DiNunzio,Michael Eglesia,Seth P. Forster,Matthew S. Lamm,Michael Lowinger,Patrick J. Marsac,Craig A. McKelvey,Robert F. Meyer,Luke Schenck,Graciela Terife,Gregory M. Troup,Brandye Smith-Goettler,Cindy Starbuck +13 more
TL;DR: Novel applications, such as devolatilization and development using quality by design, allow for the technology to support both drug substance and drug product manufacturing.
Book ChapterDOI
Orally disintegrating films of biopolymers for drug delivery
Vitor Augusto dos Santos Garcia,Josiane Gonçalves Borges,Fernanda Maria Vanin,Rosemary Aparecida de Carvalho +3 more
TL;DR: In this paper, the main biopolymers used for the production of orally disintegrating films, and the different techniques used for their production, innovations in the area, and technique used for characterization, such as assessment of disintegration time, muco-coverage, surface pH, and dissolution tests.
Enhancement of dissolution rate and bioavailability of Paliperidone by Hot Melt Extrusion technique
A. Pandey,B. Rath,A. K. Dwivedi +2 more
TL;DR: In this article, the authors used copovidone as a hydrophilic polymer with plasticizers like PEG (6000 and 20000), stearic acid and cetosterayl alcohol to increase the dissolution and bioavailability of paliperidone by amorphization.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
Book
Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.