Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Patent
Crystalline forms of nicotinoyl ribosides, modified derivatives thereof, and phosphorylated analogs thereof, and methods of preparation thereof
Marie E. Migaud,Philip Redpath,Kerri Crossey,Richard Cunningham,Aron Erickson,Richard Nygaard,Amanda Storjohann +6 more
TL;DR: In this paper, the authors provided novel crystalline forms of nicotinoyl riboside compounds or derivatives of formula (I): wherein X −, Z 1, Z 2, n, R 1, R 2, R 3, R 4, R 5, R 6, R 7, and R 8 are described, modified derivatives thereof, and phosphorylated analogs thereof, or salts, solvates, or prodrugs thereof; and methods of preparation thereof.
Journal ArticleDOI
Micro-Injection Moulding of Poly(vinylpyrrolidone-vinyl acetate) Binary and Ternary Amorphous Solid Dispersions.
Romina Pezzoli,Michael Hopkins Jnr,Guillaume Direur,Noel M. Gately,John G. Lyons,Clement L. Higginbotham +5 more
TL;DR: Overall, the production of tablets of amorphous solid dispersions (ASD), coupling hot-melt extrusion (HME) and µIM, proved to be a successful approach towards a continuous automated manufacturing process to improve the aqueous solubility of poorly water-soluble drugs.
Patent
Extended release, abuse deterrent dosage forms
TL;DR: Extended release, abuse deterrent dosage forms comprising crush-resistant controlled-release particles that provide abuse deterrent properties to the dosage forms are presented in this paper, which are prepared by a hot melt extrusion process and contain plastic/elastic polymers and at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof.
Book ChapterDOI
Crystal Growth of Pharmaceuticals from Melt
J.S. Redinha,A.J. Lopes Jesus +1 more
TL;DR: Brittain et al. as discussed by the authors proposed a method for the preparation of crystalline powders and single crystals from solutions by decreasing temperature, solvent evaporation or by the diffusion of a much poorer solvent in solution.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
Book
Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.