Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Citations
198 citations
Cites background from "Pharmaceutical Applications of Hot-..."
...The molten material will then be pumped through a die, which will give a fixed shape that forms the extrudate [18]....
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...The mo ten mat rial will then be pumped through a die, which will give a fixed shape that forms the extrudate [18]....
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...Occasionally, the single screw extruder can also be starve fed, where a feed system sets the mass flow rate and the output rate is independent of the screw speed [18]....
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...The counter-rotating screws can produce very high shear forces as the materials are squeezed into the gaps between the two screws [18]....
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...In the single screw extruder, there is only one screw in the extruder, which is used for feeding, melting, devolatilising and pumping [18]....
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189 citations
Cites methods from "Pharmaceutical Applications of Hot-..."
...HME is a widely used processing technology in the polymer and food industries and has been recently demonstrated to be a viable method to prepare several types of dosage forms and drug delivery systems (26, 27)....
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188 citations
Cites background or methods from "Pharmaceutical Applications of Hot-..."
...In the last 15 years, over 150 research papers and many reviews [1-5] have been published on the subject....
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...For a more detailed discussion on extruder types and designs, including processing, readers are referred to a recent publication on the subject [4] ....
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...The stability of such extrudates can be assessed by thermo-analytical techniques such as hot stage microscopy, differential scanning calorimetry, thermogravimetric analysis, as well as non-thermal techniques such as scanning electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, solid-state nuclear magnetic resonance spectroscopy and high performance liquid chromatography [4] ....
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175 citations
173 citations
Cites background from "Pharmaceutical Applications of Hot-..."
...Researches on new SDs and the related fabrication processes have been widely reported in literature during the past several decades [19-21], and today a lot of SD products are marketed: Kaletra (Abbott), Intelence (Tibotec), Certican (Novartis), Isoptin SR-E (Abbott), Nivadil and Prograf (Fujisawa Pharmaceutical Co....
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References
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