Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets
Abdullah S. Alshetaili,Bjad K. Almutairy,Saad M. Alshahrani,Eman A. Ashour,Roshan V. Tiwari,Sultan Alshehri,Xin Feng,Bader B. Alsulays,Soumyajit Majumdar,Nigel Langley,Karl Kolter,Andreas Gryczke,Scott T. Martin,Michael A. Repka +13 more
TL;DR: To formulate face-cut, melt-extruded pellets, and to optimize hot melt process parameters to obtain maximized sphericity and hardness by utilizing Soluplus® as a polymeric carrier and carbamazepine as a model drug, was formulated.
Journal ArticleDOI
Influence of lidocaine forms (salt vs. freebase) on properties of drug-eudragit® L100-55 extrudates prepared by reactive melt extrusion.
TL;DR: It is concluded that different forms of lidocaine resulted in different drug–polymer interactions and distinctive physicochemical properties of extrudates.
Journal ArticleDOI
Twin-screw melt granulation: Current progress and challenges.
TL;DR: This review summarizes the current progress of TSMG while highlighting how various formulation and process parameters affect the physicochemical properties of granules.
Journal ArticleDOI
Understanding polymer-lipid solid dispersions-The properties of incorporated lipids govern the crystallisation behaviour of PEG
TL;DR: There is a large difference in the behaviour of PEG depending on lipid added, explained in terms of molecular properties for the lipids, demonstrated by the use of PLS modelling to describe the behaviourof PEG solid dispersions.
Journal ArticleDOI
In-line dynamic torque measurement in twin-screw extrusion process
M. Köster,M. Thommes +1 more
TL;DR: In this article, a corotating twin-screw extruder was equipped with a torque gauge as a tool for process monitoring, which correlated linearly with the water content in a wet extrusion process.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
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Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.