Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Development of an automated multi-stage continuous reactive crystallization system with in-line PATs for high viscosity process
Chuntian Hu,Joshua E. Finkelstein,Wei Wu,Khrystyna Shvedova,Christopher J. Testa,Stephen C. Born,Bayan Takizawa,Thomas F. O’Connor,Xiaochuan Yang,Sukumar Ramanujam,Salvatore Mascia +10 more
TL;DR: An automated multi-stage continuous reaction system with in-line PATs for a high viscosity reactive crystallization process was developed in this article, where a forward-backward burst pumping strategy was developed to smoothly transfer the highly viscous hot slurry from one vessel to the next.
Journal ArticleDOI
Creation of polylactide vascular scaffolds with high compressive strength using a novel melt-tube drawing method
Seung Hyuk Im,Seung Hyuk Im,Su Jeong Park,Su Jeong Park,Justin J. Chung,Youngmee Jung,Youngmee Jung,Soo Hyun Kim,Soo Hyun Kim,Soo Hyun Kim +9 more
TL;DR: The poly(lactide) tubular scaffold fabricated using the MD process showed improved compressive strength and recovery ability as well as a smooth surface, and the MD-tube displayed extensive chain orientation and increased crystallinity.
Journal ArticleDOI
Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt Extrusion Formulations
Gauri Shadambikar,Thomas Kipping,Nicole Di-Gallo,Alessandro-Giuseppe Elia,Anja-Nadine Knüttel,Daniel Franz Treffer,Michael A. Repka +6 more
TL;DR: A novel approach to screen the polymers by overcoming the disadvantage of conventional HME screening by using a minimum quantity of active pharmaceutical ingredient (API) in order to prove the effectiveness of VCM as a screening tool for HME-based formulations.
Journal Article
A Review of Hot Melt Extrusion Technique
Ankit Patel,Deepak Sahu,Ashok Dashora,Rahul Garg,Piyush Agraval,Pratik Patel,Parth J Patel,Gaurang Patel +7 more
TL;DR: In this paper, a review about the types of Extruder, solid dispersion and Application of the Hot Melt Extrusion (HME) to the pharmaceutical industries is presented.
Journal ArticleDOI
A comprehensive overview of extended release oral dosage forms manufactured through hot melt extrusion and its combination with 3D printing
TL;DR: In this article, a review of pharmaceutical approaches used to control and sustain drug release in oral formulations by Hot-Melt Extrusion (HME) and its combination with FDM 3D printing is presented.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
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Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.