Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
An innovative matrix controlling drug delivery produced by thermal treatment of DC tablets containing polycarbophil and ethylcellulose.
Gabriele Caviglioli,Sara Baldassari,Paola Cirrincione,Eleonora Russo,Brunella Parodi,Paolo Gatti,Giuliana Drava +6 more
TL;DR: An innovative matrix, produced by thermal treatment on direct compression tablets containing polycarbophil and ethylcellulose, identified as matrix forming polymers, and able to control the release of diltiazem hydrochloride, was developed, showing stability for at least 2.7 years at RT conditions.
Journal ArticleDOI
Design and fabrication of a low-cost pilot-scale melt-processing system
TL;DR: In this article, a bench-top, sub-milliliter volume extrusion and injection-molding device was designed and evaluated for molding polymers and polymer composites.
Journal ArticleDOI
Dry heat forced degradation of buserelin peptide: kinetics and degradant profiling.
Matthias D'Hondt,Maria Fedorova,Chien-Yu Peng,Bert Gevaert,Lien Taevernier,Ralf Hoffmann,Bart De Spiegeleer +6 more
TL;DR: In order to evaluate its hot-melt extrusion (HME) capabilities, buserelin powder in its solid state was exposed to elevated temperatures for prolonged time periods and showed no significant degradation, thus demonstrating the HME capabilities of buSErelin.
Journal ArticleDOI
A Miniaturized Extruder to Prototype Amorphous Solid Dispersions: Selection of Plasticizers for Hot Melt Extrusion.
Matthias E. Lauer,Reto Maurer,Anne De Paepe,Cordula Stillhart,Laurence Jacob,Rajesh James,Yuki Kojima,René Rietmann,Tom Kissling,Joost A. van den Ende,Sabine Schwarz,Olaf Grassmann,Susanne Page +12 more
TL;DR: A miniaturized extrusion device was developed and Hypromellose acetate succinate type L based extrudates containing the model drugs neurokinin-1 (NK1) and cholesterylester transfer protein (CETP) were manufactured, plasticizers were added and their impact on dissolution and solid-state properties were assessed.
Journal ArticleDOI
Orodispersible films - Recent developments and new applications in drug delivery and therapy.
TL;DR: Orodispersible films (ODF) as discussed by the authors are innovative drug formulations that introduce a promising approach to pharmacotherapy, which represent single- or multi-layer polymer films that show sufficient stability but disintegrate easily.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
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Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.