Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
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Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs.
TL;DR: Critical aspects and recent advances in formulation, preparation and characterization of solid dispersions as well as in-depth pharmaceutical solutions to overcome some problems and issues that limit the development and marketability of solid dispersion products are reviewed.
Journal ArticleDOI
Effect of geometry on drug release from 3D printed tablets.
Alvaro Goyanes,Pamela Robles Martinez,Asma B. M. Buanz,Abdul Basit,Simon Gaisford,Simon Gaisford +5 more
TL;DR: This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.
Journal ArticleDOI
Manufacture and characterization of mucoadhesive buccal films.
TL;DR: This review will consider the literature that describes the manufacture and characterization of mucoadhesive buccal films and hot-melt extrusion has been explored as an alternative manufacturing process and has yielded promising results.
Journal ArticleDOI
3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics
Alvaro Goyanes,Alvaro Goyanes,Jie Wang,Asma B. M. Buanz,Ramón Martínez-Pacheco,Richard Telford,Simon Gaisford,Simon Gaisford,Abdul Basit +8 more
TL;DR: The study confirms the potential of 3D printing to fabricate multiple-drug containing devices with specialized design configurations and unique drug release characteristics, which would not otherwise be possible using conventional manufacturing methods.
References
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Journal Article
Properties of ethyl cellulose films for extended release. II: Influence of plasticizer content and coalescence conditions when using aqueous dispersions
Journal Article
Darstellung wirkstoffhaltiger Extrusionsformlinge auf der Basis von Thermoplasten. II: Untersuchugen zur Optimierung der Wirkstofffreigabe
R. Mank,H. Kala,M. Richter +2 more
Journal ArticleDOI
Controlled release contraceptive devices: a status report
TL;DR: This review emphasizes controlled release contraceptive systems that are under clinical development or that already have reached the market, including the single-rod contraceptive implant, the biodegradable hollow fibre and the 2-compartment combined contraceptive vaginal ring.
Journal ArticleDOI
Stability of Extruded 17β-Estradiol Solid Dispersions
TL;DR: In this paper, different analytical methods were applied showing that no recrystallization occurred after treating melt extruded solid dispersions with 17β-Estradiol as the model drug with heat or water vapor.
Journal ArticleDOI
Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing
TL;DR: Investigation of the stability of an amorphous drug, Delta(9)-tetrahydrocannabinol (THC) in polymer-based transmucosal systems found it to be chemically and thermally unstable at such high temperatures, and matrix fabrication was found to be favorable at relatively lower temperatures.