Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs.
TL;DR: Critical aspects and recent advances in formulation, preparation and characterization of solid dispersions as well as in-depth pharmaceutical solutions to overcome some problems and issues that limit the development and marketability of solid dispersion products are reviewed.
Journal ArticleDOI
Effect of geometry on drug release from 3D printed tablets.
Alvaro Goyanes,Pamela Robles Martinez,Asma B. M. Buanz,Abdul Basit,Simon Gaisford,Simon Gaisford +5 more
TL;DR: This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.
Journal ArticleDOI
Manufacture and characterization of mucoadhesive buccal films.
TL;DR: This review will consider the literature that describes the manufacture and characterization of mucoadhesive buccal films and hot-melt extrusion has been explored as an alternative manufacturing process and has yielded promising results.
Journal ArticleDOI
3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics
Alvaro Goyanes,Alvaro Goyanes,Jie Wang,Asma B. M. Buanz,Ramón Martínez-Pacheco,Richard Telford,Simon Gaisford,Simon Gaisford,Abdul Basit +8 more
TL;DR: The study confirms the potential of 3D printing to fabricate multiple-drug containing devices with specialized design configurations and unique drug release characteristics, which would not otherwise be possible using conventional manufacturing methods.
References
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Characterization of Solid Dispersion Phase Transitions Using a New Optical Thermal Analyzer
TL;DR: In this paper, the phase transitions occurring during the heating of progesterone PEG6000, and the solid dispersions (3% and 20% w/w) were studied using differential scanning calorimetry and optical thermal analysis.
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In Vivo Performance of Wax Matrix Granules Prepared by a Twin-Screw Compounding Extruder
Yasuhiko Miyagawa,Hiroshi Sato,Toshio Okabe,Tetsuyuki Nishiyama,Masaharu Miyajima,Hisakazu Sunada +5 more
TL;DR: Good correlation between one in vitro dissolution parameter (mean dissolution time, MDT) and two in vivo parameters (AUC12 and MRT) suggested that it would be possible to design WMGs with a desired in vivo performance by controlling HPC content.
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A study of enteric-coated liquid-filled hard gelatin capsules with biphasic release characteristics
TL;DR: The present investigation demonstrates the importance of ensuring a sufficient enteric-coating level for oral dosage vehicles to maintain post gastric dissolution characteristics and illustrates the need for a reliable means of assessing enteric coat performance in vitro.
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Characterization of Hydrogen Bonding between Selected Barbiturates and Polyethylene Glycol 4000 by IR Spectral Analysis
TL;DR: Several barbiturates and primidone were equilibrated with polyethylene glycol 4000 in pyridine and IR spectral properties of these samples indicate that seven disubstituted bar Biturates complex withpolyethylene Glycol 4000 while five disubStitutedbarbiturate and two trisubst ituted bar biturates as well as primid one do not.
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Influence of a lipophilic thermal lubricant on the processing conditions and drug release properties of chlorpheniramine maleate tablets prepared by hot-melt extrusion
TL;DR: In this article, the influence of a lipophilic thermal lubricant on the processing conditions and properties of chlorpheniramine maleate (CPM) tablets prepared by hot-melt extrusion was investigated.