Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Citations
1,201 citations
Cites background from "Pharmaceutical Applications of Hot-..."
...The mixture is subsequently forced through a die to produce an extrudate of uniform shape (Crowley et al., 2007)....
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...More recently, hot-melt extrusion (HME) has grown in popularity as it appears to address many of the limitations of simple fusion methods (Breitenbach, 2002; Crowley et al., 2007; Repka et al., 2007)....
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510 citations
494 citations
Cites methods from "Pharmaceutical Applications of Hot-..."
...Several research groups have demonstrated HME processes as a viable method to prepare a wide range of accepted pharmaceutical drug delivery systems, including granules, pellets, transdermal patches, transmucosal films systems and implants (Breitenbach, 2002; Crowley et al., 2007; Fonteyne et al., 2013)....
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381 citations
Cites methods from "Pharmaceutical Applications of Hot-..."
...Hot-melt extrusion has been used for the manufacture of controlled-release matrix tablets, pellets, and granules [84], as well as orally disintegrating films [85]....
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359 citations
References
138 citations
134 citations
"Pharmaceutical Applications of Hot-..." refers background in this paper
...Ghebremeskel and co-workers investigated the overall performance of solid dispersions processed using surfactants as plasticizers (Ghebremeskel et al., 2006)....
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133 citations
132 citations
"Pharmaceutical Applications of Hot-..." refers background or result in this paper
...These results were in contrast to those reported by Aitken-Nichol et al. (1996). The discrepancy between the two studies is likely due to polymer compatibility between polyethylene and Eudragit E100 in the Aitken-Nichol study....
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...Currently, films for transdermal/transmucosal drug delivery and wound care applications are produced more frequently by casting from organic or aqueous solvents (Aitken-Nichol et al., 1996)....
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127 citations
"Pharmaceutical Applications of Hot-..." refers methods in this paper
...successfully prepared spherical controlled release theophylline pellets by a hot-melt extrusion and spheronization process (Young et al., 2002)....
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