Pharmacodynamic Effects of a d-Amino Acid Oxidase Inhibitor Indicate a Spinal Site of Action in Rat Models of Neuropathic Pain
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...inhibitor, which increased D-serine concentrations in brain and plasma,reduced spontaneous neuronal activity in both central and peripheral recordings and alsoattenuated pain behaviors in rat models of neuropathic and inflammatory pain[34]....
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"Pharmacodynamic Effects of a d-Amin..." refers background in this paper
...Since DAAO has been reported to be expressed highly in the cerebellum (Wang and Zhu, 2003), this brain region exhibits lower baseline levels of D-serine (Hashimoto et al., 1993; Wang and Zhu, 2003)....
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"Pharmacodynamic Effects of a d-Amin..." refers background in this paper
...Although D-serine occupancy of the glycine site on NR1 subunits serves to increase NMDA receptor activation, this increase would occur only in neuronal regions where this site is not already saturated by glycine or D-serine (Mothet et al., 2000; Panatier et al., 2006; Heffernan et al., 2009; Oliet and Mothet, 2009; Papouin et al., 2012)....
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...…site on NR1 subunits serves to increase NMDA receptor activation, this increase would occur only in neuronal regions where this site is not already saturated by glycine or D-serine (Mothet et al., 2000; Panatier et al., 2006; Heffernan et al., 2009; Oliet and Mothet, 2009; Papouin et al., 2012)....
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121 citations
"Pharmacodynamic Effects of a d-Amin..." refers background in this paper
...Consistent with this idea, D-serine was recognized to have effects on another glutamate receptor, iGluRdelta (Naur et al., 2007)....
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